Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have
revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory …

The lymphocyte activation gene-3 (LAG-3) molecule is a T cell activation Ag closely related
to CD4 at the gene and protein levels. We investigated whether LAG-3 itself may down …

T cell Ig domain and mucin domain protein 1 (TIM-1) is a costimulatory molecule that
regulates immune responses by modulating CD4+ T cell effector differentiation. However …

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is an inhibitory receptor belonging to
the CD28 immunoglobulin subfamily, expressed primarily by T-cells. Its ligands, CD80 and …

C Ytotoxic T lymphocyte-assodated molecule-4 (CTLA-4) is a lymphocyte cell surface
receptor originally discovered in a search for molecules having a role in T cell cytotoxicity …

Inhibitory receptors play a crucial role in regulating CD8 T-cell function during chronic viral
infection. T-cell Ig-and mucin-domain–containing molecule–3 (Tim-3) is well known to …

The immune system ensures optimum T-effector (Teff) immune responses against invading
microbes and tumor antigens while preventing inappropriate autoimmune responses …

CTLA-4, initially described as a membranebound molecule, is a costimulatory receptor
transducing a potent inhibitory signal. Increasing evidence shows the CTLA-4 gene to be an …

During the past several years, the critical role of costimulatory molecules in regulating T cell
responses has been demonstrated. Costimulatory molecule CD28 enhances whereas CTLA …

CTLA-4 proteins contribute to the suppressor function of regulatory T cells (Tregs), but the
mechanism by which they do so remains incompletely understood. In the present study, we …