To understand the role of cytotoxic T cells in liver damage and viral control, we used human
histocompatibility leukocyte antigen (HLA)-peptide tetramers that allow direct ex vivo …

Hepatitis B virus (HBV) is a noncytopathic virus, and the recognition of infected hepatocytes
by HBV-specific CD8 cells has been assumed to be the central mechanism causing both …

Background & Aims: Cytotoxic T cells have been suggested to be responsible for lysis of
hepatitis B virus (HBV)-infected hepatocytes and control of virus infection. The frequency …

Resolution of hepatitis B virus (HBV) infection was believed to be attributed to the cytotoxic T
cell–mediated killing of infected hepatocytes. However, studies in HBV transgenic mice and …

Clearance of the hepatitis B virus (HBV), a noncytopathic double-stranded DNA virus,
requires the coordinated response of innate and adaptive, humoral and cellular immune …

During acute type B hepatitis, the proportion of inducer to cytotoxic/suppressor T‐cells is
decreased due to an increase in the concentration of suppressor cells. Similar changes are …

The aim of this study was to elucidate the molecular basis for viral clearance and liver
disease in the pathogenesis of hepatitis B virus (HBV) infection. Using transgenic mice that …

During infection with hepatitis B or C viruses, cytotoxic T lymphocytes (CTLs) have been
implicated as both the mediators of protection and the principal effectors of liver pathology …

ABSTRACT CD8 T cells exert their antiviral function through cytokines and lysis of infected
cells. Because hepatocytes are susceptible to noncytolytic mechanisms of viral clearance …

BACKGROUND/AIMS: Characteristics of the intrahepatic virus-specific T-cell response in
patients with acute hepatitis B virus (HBV) infection have not been studied due to the risk of …