T4 is the main product secreted by the thyroid follicular cells and is regarded as a precursor
of the bioactive hormone T3, most of which is produced by outer ring deiodination of T4 in …

The human thyroid gland secretes thyroid hormones under the control of the hypothalamus-
pituitary-periphery feedback axis already during the last fetal trimester and is the only …

It is over 40 years since the original demonstration that thyroxine (T4), the principal secretory
product of the thyroid, is deiodinated, to 3, 5, 3'-tri-iodothyronine (T3) in peripheral …

The type I iodothyronine deiodinase (ID-I) in liver and kidney converts the prohormone
thyroxine (T 4) by outer ring deiodination (ORD) to bioactive 3, 3′, 5-triiodothyronine (T 3) …

Publisher Summary This chapter explores the metabolic pathways of thyroid hormones. In
vitro studies have been employed to study the nature of this peripheral regulatory …

Deiodination is the foremost pathway of thyroid hormone metabolism not only in quantitative
terms but also because thyroxine (T4) is activated by outer ring deiodination (ORD) to 3, 3', 5 …

The major thyroid hormone (TH) secreted by the thyroid gland is thyroxine (T4).
Triiodothyronine (T3), formed chiefly by deiodination of T4, is the active hormone at the …

Liver is an important site for the peripheral production of T3 by outer ring deiodination (ORD)
of T4 as well as for the clearance of plasma rT3, which is produced by inner ring …

Thyroxine (T4) is a prohormone and must be activated to 3, 5, 3′-triiodothyronine (T3) by
either type 1 (D1) or type 2 (D2) selenodeiodinase. A third deiodinase (D3) inactivates T3 or …

Previous studies have shown that the inner ring deiodination (IRD) of T3 and the outer ring
deiodination (ORD) of 3, 3'-diiodothyronine are greatly enhanced by sulfate conjugation …