Myostatin is a negative regulator of muscle growth and fiber size. Changes in myostatin
expression might contribute to changes in muscle mass associated with various conditions …

Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of
the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle …

Inhibition of myostatin, which negatively regulates skeletal muscle growth, is a promising
strategy for the treatment of muscle atrophic disorders, such as muscular dystrophy …

Myostatin is a newly described member of the TGF-β superfamily acting as a secreted
negative regulator of skeletal muscle mass in several species, but whose mode of action …

The presence of sufficient skeletal muscle mass is of paramount importance for body
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …

Myostatin is hypothesized to regulate skeletal muscle mass and to be a potential target for
therapeutic intervention in sarcopenia. To clarify whether myostatin is invariably associated …

THE PLASTICITY OF SKELETAL muscle continues to fascinate physiologists and cell
biologists. Many of the key molecules in the pathways that signal growth or atrophy of …

Myostatin, a negative regulator of skeletal muscle growth, is a promising target for treating
muscle atrophic disorders. Recently, we discovered a minimal myostatin inhibitor 1 …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

Myostatin is a negative regulator of muscle growth, and absence of the functional myostatin
protein leads to the heavy muscle phenotype in both mouse and cattle. Although the role of …