C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and …

S Verma, MA Kuliszewski, SH Li, PE Szmitko, L Zucco… - Circulation, 2004 - Am Heart Assoc
Background—Myocardial ischemia provides a potent stimulus to angiogenesis, and the
mobilization and differentiation of endothelial progenitor cells (EPCs) has been shown to be …

C-reactive protein impairs angiogenic functions and decreases the secretion of arteriogenic chemo-cytokines in human endothelial progenitor cells

W Suh, KL Kim, JH Choi, YS Lee, JY Lee… - Biochemical and …, 2004 - Elsevier
C-reactive protein (CRP), a predictor of future cardiovascular diseases, has been reported to
damage the vascular wall by inducing endothelial dysfunction and inflammation. This …

C-reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells

H Fujii, SH Li, PE Szmitko, PWM Fedak… - … , and vascular biology, 2006 - Am Heart Assoc
Objective—C-reactive protein (CRP) has been suggested to participate in the development
of atherosclerosis, in part, by promoting endothelial dysfunction and impairing endothelial …

Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation

J George, E Goldstein, S Abashidze… - European heart …, 2004 - academic.oup.com
Background Endothelial progenitor cells (EPC) are present in peripheral blood and can
develop a functional endothelial phenotype. The number and function of circulating EPCs …

Endothelial progenitor cell dysfunction in cardiovascular diseases: role of reactive oxygen species and inflammation

CP Lin, FY Lin, PH Huang, YL Chen… - BioMed Research …, 2013 - Wiley Online Library
Endothelial progenitor cells (EPCs) move towards injured endothelium or inflamed tissues
and incorporate into foci of neovascularisation, thereby improving blood flow and tissue …

Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular …

C Schmidt-Lucke, L Rössig, S Fichtlscherer, M Vasa… - Circulation, 2005 - Am Heart Assoc
Background—The maintenance of endothelial integrity plays a critical role in preventing
atherosclerotic disease progression. Endothelial progenitor cells (EPCs) were …

p38 mitogen-activated protein kinase downregulates endothelial progenitor cells

FH Seeger, J Haendeler, DH Walter, U Rochwalsky… - Circulation, 2005 - Am Heart Assoc
Background—Transplantation of endothelial progenitor cells (EPCs) improves
neovascularization after ischemia, but patients with coronary artery disease (CAD) or …

Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells

Y Zhang, DA Ingram, MP Murphy… - American Journal …, 2009 - journals.physiology.org
Cell therapy with endothelial progenitor cells (EPCs) is an emerging therapeutic option to
promote angiogenesis or endothelial repair. Although the release of angiogenic paracrine …

Role of inflammation and oxidative stress in endothelial progenitor cell function and mobilization: therapeutic implications for cardiovascular diseases

D Tousoulis, I Andreou, C Antoniades, C Tentolouris… - Atherosclerosis, 2008 - Elsevier
Endothelial progenitor cells (EPCs) are mobilized from the bone marrow into the peripheral
circulation, home to sites of injury, and incorporate into foci of neovascularization, thereby …

Peripheral Blood CD34+KDR+ Endothelial Progenitor Cells Are Determinants of Subclinical Atherosclerosis in a Middle-Aged General Population

GP Fadini, A Coracina, I Baesso, C Agostini, A Tiengo… - Stroke, 2006 - Am Heart Assoc
Background and Purpose—Disruption of the endothelial layer is the first step in the
atherogenic process. Experimental studies have shown that endothelial progenitor cells …