A method is described for measurement of chlorpropamide, tolbutamide, and the
tolbutamide metabolites hydroxymethyltolbutamide and carboxytolbutamide in blood. It …

We have developed a rapid, sensitive and specific method for the quantitation of serum
levels of two antidiabetic sulfonylureas, chlorpropamide (I) and tolbutamide (II). Thermally …

Methods Serum concentrations of both chlorpropamide and tolbutamide were determined by
the same analytical method. This method, developed by Toolan and Wagner for …

A GLC procedure was developed for the quantitative estimation of intact chlorpropamide
and tolbutamide concentrations in plasma; the drugs are used as mutual internal standards …

N-Methyl and N-methyltrlfluoroacetyl, N-methylpentalluo-ropropionyl, and-
methylheptafluorobutyryl derivatives of the sulfonylureas tolbutamide, hydroxyltolbutamide …

A sensitive and specific high‐performance liquid chromatographic procedure for the
determination of chlorpropamide or tolbutamide in plasma in the presence of their …

Conditions for the extractive alkylation of eight sulphonylurea hypoglycemic drugs have
been evaluated. Extractive methylation of the compounds was achieved within 90 min using …

Tolbufamide (I-butyL3-@ tol~ &l~ honyl) ur&a) and chlorpropamide (I-prop@ 3-@ chlorph+
yl sulphonyl) urea)-are two of the stiIphonylurea derivaties uzxxt as or&l hypoglycaemic …

An improved method for the gas‐liquid chromatographic estimation of tolbutamide and
chlorpropamide in plasma is described. The drugs are extracted into toluene, back …

Assays exist for the determination of the oral hypoglycemic sulphonylureas, tolbutamide and
chlorpropamide, in biological fluids. The most common involve modification of Spingler's …