Peripheral blood T lymphocytes from 21 patients with chronic HBV infection were incubated
with autologous hepatocytes in a microcytotoxicity assay. Cytotoxicity was significantly …

Previous studies demonstrated that peripheral blood lymphocytes are cytotoxic to
autologous hepatocytes in patients with chronic hepatitis B virus infection. We examined …

Hepatitis B core antigen (HBcAg)-specific T cell lines were established from hepatic
lymphomononuclear cells derived from five patients with chronic active hepatitis B. No …

Highly purified CD4+ T cells isolated from liver biopsies of patients with hepatitis B virus-
induced CAH had a strong cytotoxic activity and were comprised of a substantial number of …

Clearance of the hepatitis B virus (HBV), a noncytopathic double-stranded DNA virus,
requires the coordinated response of innate and adaptive, humoral and cellular immune …

We have previously reported the establishment and preliminary characterization of
polyclonal hepatitis B virus (HBV) nucleoprotein (HBcAg)-specific CD4+ and CD8+ T cell …

The Ag specificity and cytotoxic function of human T cell clones, generated from lymphocytes
infiltrating the liver of a chronic hepatitis B patient, were studied. Both class I-and class II …

It has been suggested that cytotoxic T cells are involved in the recognition and lysis of the
infected hepatocytes in chronic hepatitis B virus infection, and that the target antigen is …

In a micrototoxicity assay, lymphocytes from ten out of sixteen patients with HBsAg-negative
chronic active hepatitis have been shown to be cytotoxic to autologous hepatocytes isolated …

Infection of man and chimpanzees with the hepatitis B virus (HBV) is associated with diffuse
hepatocellular infection and variable manifestations of disease which may not only reflect …