Retaining glycosidases have been extensively studied for the synthesis of oligosaccharides
and glycoconjugates as a convenient enzymatic approach to achieve the required regio-and …

Glycosynthases, engineered glycoside hydrolases that are able to synthesize glycans in
quantitative yields without hydrolyzing them, are among the most interesting tools for the …

In recent decades, there has been a boom in carbohydrate chemistry, evoked by the
increasing need for new carbohydrate materials and by the dynamic development of …

In oligosaccharide synthesis the chemo‐enzymatic approach is often chosen to obtain the
desired glycosidic bond by exploiting the exquisite substrate specificity and stereoselectivity …

The mutation of putative acid/base and nucleophile of the active sites of retaining glycosyl
hydrolases, together with kinetic analysis of the mutants, and stereochemical identification of …

Oligosaccharide synthesis is becoming increasingly important to the pharmaceutical
industry because these biomolecules have potential application as therapeutics. Enzymatic …

The many advances in glycoscience have more and more brought to light the crucial role of
glycosides and glycoconjugates in biological processes. Their major influence on the …

Enzymes are indispensable tools in modern organic synthesis. Recent progress in cloning
techniques, microbiology and protein purification supply an ever growing number and …

Glycosyltransferases are useful synthetic tools for the preparation of natural
oligosaccharides, glycoconjugates and their analogues. High expression levels of …

The expanding field of glycobiology requires tools for the synthesis of structurally defined
oligosaccharides and glycoconjugates, while any potential therapeutic applications of sugar …