Expression of antioxidant and phase 2 xenobiotic metabolizing enzyme genes is regulated
through cis-acting sequences known as antioxidant response elements. Transcriptional …

Nrf2 binds to the antioxidant response element and regulates expression and antioxidant
induction of a battery of chemopreventive genes. In this study, we have identified nuclear …

Transcription factor Nrf3 (NF-E2 p45-related factor 3) is targeted to the endoplasmic
reticulum (ER). Mouse Nrf3 is subject to proteolysis, Asn glycosylation, and deglycosylation …

Nrf1 is a member of the vertebrate Cap'n'Collar (CNC) transcription factor family that
commonly contains a unique basic-leucine zipper domain. Among CNC family members …

Basic leucine zipper (bZIP) protein Nrf2 is a key transcription factor mediating the antioxidant
response. Under homeostatic conditions Nrf2 is anchored to cysteine-rich Keap1 and …

Keap1 is a negative regulator of Nrf2, a bZIP transcription factor that mediates adaptation to
oxidative stress. Previous studies suggested this negative regulation is a consequence of …

Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and
lipids, and is implicated in various human diseases including cancer, neurodegeneration …

Nrf2 (NF-E2-related factor 2) is a central transcription factor involved in the transcriptional
activation of many genes encoding phase II drug-metabolizing enzymes via the antioxidant …

Nrf2, a basic leucine zipper transcription factor, is an essential activator of the coordinated
transcription of genes encoding antioxidant enzymes and phase II detoxifying enzymes …

Nrf1 [NF-E2 (nuclear factor-erythroid 2)-related factor 1] is a CNC (cap'n'collar) bZIP (basic-
region leucine zipper) transcription factor that is tethered to ER (endoplasmic reticulum) and …