Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ)
are key regulators of cell proliferation and organ size; however, their physiological …

Background & Aims Hepatic stellate cell activation is a wound-healing response to liver
injury. However, continued activation of stellate cells during chronic liver damage causes …

In response to liver injury, the liver undergoes a regeneration process to retain its mass and
function. However, the regeneration mechanism has not been fully clarified. This study …

Although the signaling pathways involved in normal liver regeneration have been well
characterized, less has been done for livers affected by chronic tissue damage. These …

Yes-associated protein (YAP) is a significant downstream protein in the Hippo signaling
pathway with important functions in cell proliferation, apoptosis, invasion and migration. YAP …

Background & Aims Hepatic ischemia-reperfusion injury (IRI) is a major complication of
hemorrhagic shock, liver resection and transplantation. YAP, a key downstream effector of …

Background & Aims Chronic failure of mechanisms that promote effective regeneration of
dead hepatocytes causes replacement of functional hepatic parenchyma with fibrous scar …

Background and aims: Biological mechanisms that control liver regeneration remain poorly
defined. However, these mechanisms are remarkable issues in the clinic that affect …

The Hippo signaling pathway has been implicated in mammalian organ size regulation and
tumor suppression. Specifically, the Hippo pathway plays a critical role regulating the activity …

Hepatic stellate cells (HSCs) are resident mesenchymal cells in the space of Disse
interposed between liver sinusoidal endothelial cells and hepatocytes. Thorn-like …