In this paper, we synthesized a range of amphiphilic Janus dendrimers, which consisted of
acidic amino acid and naproxen molecules as the peripheral groups, as novel potential …

To construct a water-soluble and bone-targeting non-steroidal anti-inflammatory dendritic
drug carrier, a series of Asp oligopeptides and naproxen based poly amido-ester Janus …

The development of dual-targeting drug delivery system is helpful to overcome the poor
physiochemical properties of chemotherapeutic agents. The RGD sequence has a potential …

Bone targeting is one of the most potentially valuable therapeutic methods for medically
treating bone diseases, such as osteoarthritis, osteoporosis, nonunion bone defects, bone …

We developed a bone-targeting dendrimer for the delivery of anti-tumour agents and
effective treatment of bone metastasis, in which alendronate (ALN), a bone-targeting moiety …

The second-and third-generation multiple dendrimers based on naproxen in core and Asp
(4–6) oligopeptides in periphery were synthesized in a convergent approach and well …

In this study, we aimed to develop a polyethylene glycol (PEG)-conjugated third generation
polyamidoamine (PAMAM) dendrimer with multiple carboxylic acids as a bone-targeting …

Bone-drug targeting therapies using nanoparticles based on targeting ligands remain
challenging due to their uptake clearance at non-target sites such as the liver, kidney, and …

Novel bone targeting naproxen prodrugs with poly (aspartic acid) moieties and with two and
three poly (aspartic acid) sequences peptide dendrimers were synthesized using a …

Osteoporosis is an age-related metabolic disease of bone, resulting in bone pain and even
bone fragility and brittle fracture. Inhibiting overactive osteoclasts while promoting osteoblast …