Our laboratory has developed a novel orthotopic implantation model of human prostate
cancer (PCa). As PCa death is not due to the primary tumor, but rather the formation of …

To study the multifaceted biology of prostate cancer, pre-clinical in vivo models offer a range
of options to uncover critical biological information about this disease. The human orthotopic …

Prostate cancer is one of the most common cancers in men in the United States.
Comprehensive understanding of the biology contributing to prostate cancer will have …

BACKGROUND Prostate cancer is the second leading cause of male death in the United
States. When diagnosed, nearly half the cases have metastatic lesions. An animal model of …

BACKGROUND An animal model of human prostate cancer LNCaP demonstrating high
rates of spontaneous metastasis from the orthotopic site after tumor implantation would be …

BACKGROUND In vivo model systems in prostate cancer research that authentically
reproduce tumor growth are still sparse. While orthotopic implantation is technically difficult …

BACKGROUND Spontaneous metastasis following implantation at the orthotopic site is a
highly desired feature in prostate cancer (CaP) models, since it would enable studies of …

In vivo animal studies are an essential component of prostate cancer research, and are
particularly critical for studying interactions between tumor cells and their microenvironment …

The 5-year survival rate for patients diagnosed with distant metastatic prostate cancer in the
United States is 30.6%. Therefore, there is a great need to develop in vivo model systems to …

Orthotopic tumor modeling is a valuable tool for pre-clinical prostate cancer research, as it
has multiple advantages over both subcutaneous and transgenic genetically engineered …