ABSTRACT Background: S-Adenosyl-l-methionine (SAMe), a natural compound, is the most
important methyl donor in the central nervous system. In several clinical trials, SAMe showed …

Major depression remains difficult to treat, despite the wide array of registered
antidepressants available. In recent years there has been a surge in the popularity of natural …

Despite the increasingly large array of antidepressants available to treat major depressive
disorder, patients continue to experience relatively modest response and remission rates. In …

Abstract s-adenosyl-l-methionine (SAMe) is a natural substance which constitutes the most
important methyl donor in transmethylation reactions in the central nervous system. Several …

Introduction‐S‐adenosyl‐l‐methionine (SAMe) is a naturally‐occurring substance which is a
major source of methyl groups in the brain. Material and methods‐We conducted a meta …

OBJECTIVE: To review existing published clinical evidence surrounding the dietary
supplement SAMe (S-adenosyl-L-methionine). DATA SOURCES: The majority of information …

Background Major depressive disorder (MDD) is a recurrent illness with high rates of
chronicity, treatment-resistance, and significant economic impact. S-Adenosylmethionine …

Abstract As many as 29% to 46% of patients with major depressive disorder (MDD) show
only partial or no response to an adequate course of an antidepressant. The current practice …

S‐adenosyl‐l‐methionine (SAMe), a naturally occurring brain metabolite, has previously
been found to be effective and tolerated well in parenteral form as a treatment of major …

Objective. To review the antidepressant efficacy of S-Adenosyl-L-Methionine (SAMe) both in
monotherapy and/or in augmentation with antidepressants to better understand its potential …