Carotenoids activate the antioxidant response element transcription system

A Ben-Dor, M Steiner, L Gheber, M Danilenko… - Molecular Cancer …, 2005 - AACR
Epidemiologic studies have found an inverse association between consumption of tomato
products and the risk of certain types of cancers. However, the mechanisms underlying this …

Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system

K Linnewiel, H Ernst, C Caris-Veyrat, A Ben-Dor… - Free Radical Biology …, 2009 - Elsevier
Induction of phase II detoxifying enzymes is a major cellular strategy for reducing the risk of
cancer. We previously reported that carotenoids activate the electrophile/antioxidant …

[HTML][HTML] The role of lycopene and its derivatives in the regulation of transcription systems: implications for cancer prevention

Y Sharoni, K Linnewiel-Hermoni, G Zango… - The American journal of …, 2012 - Elsevier
Evidence from epidemiologic studies has suggested that carotenoids, and lycopene in
particular, decrease the risk of cancer: however, not all studies support this view. To gain …

Antioxidant and anti-proliferative properties of lycopene

M Kelkel, M Schumacher, M Dicato… - Free radical …, 2011 - Taylor & Francis
The recent search for new anti-cancer drugs focuses more on natural compounds from the
regular human diet because these compounds rarely exhibit severe side-effects yet …

Enzymatic metabolites of lycopene induce Nrf2‐mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells

F Lian, XD Wang - International journal of cancer, 2008 - Wiley Online Library
Lycopene can be cleaved by carotene 9′, 10′‐oxygenase at its 9′, 10′ double bond to
form apo‐10′‐lycopenoids, including apo‐10′‐lycopenal,‐lycopenol and‐lycopenoic …

Carotenoids and transcription

Y Sharoni, M Danilenko, N Dubi, A Ben-Dor… - Archives of Biochemistry …, 2004 - Elsevier
The possible involvement of several transcription systems in the anticancer activity of
carotenoids is the focus of this review. Carotenoids modulate the basic mechanisms of cell …

Acyclic carotenoids and their oxidation mixtures inhibit the growth of HL-60 human promyelocytic leukemia cells

E Nara, H Hayashi, M Kotake, K Miyashita… - Nutrition and …, 2001 - Taylor & Francis
Lycopene has been known as a potential food component for cancer prevention, since
tomato consumption was shown to be associated with reduced risk of certain cancers. We …

Carotenoids and apocarotenoids in cellular signaling related to cancer: a review

Y Sharoni, K Linnewiel‐Hermoni… - Molecular nutrition & …, 2012 - Wiley Online Library
The basis for the vivid color of carotenoids and their antioxidant activity is the multiple
conjugated double bonds, which are characteristic for these phytonutrients. Moreover, the …

Activation of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidant-responsive element-mediated …

R Yu, JJ Jiao, JL Duh, K Gudehithlu, TH Tan… - …, 1997 - academic.oup.com
Green tea polyphenols, major constituents of green tea, are potent chemopreventive agents
in a number of experimental models of cancer in animals. The mechanisms of cancer …

Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents

J Antosiewicz, W Ziolkowski, S Kar, AA Powolny… - Planta …, 2008 - thieme-connect.com
Epidemiological studies continue to support the premise that diets rich in fruits and
vegetables may offer protection against cancer of various anatomic sites. This correlation is …