Arterial oxygen tension and oxyhemoglobin saturation (S a O 2) decrease in parallel during
hypoxia. Distinguishing between changes in oxygen tension and oxygen content as the …

Humans elicit a robust series of physiological responses to maintain adequate oxygen
delivery during hypoxia, including a transient reduction in hemoglobin-oxygen (Hb-O2) …

Acutely lowering ambient O2 tension increases ventilation in many mammalian species,
including humans and mice. Inheritance patterns among kinships and between mouse …

In this study, we investigated possible separate effects of H+ ions and CO2 on hypoxic
sensitivity in humans. We also examined whether hypoxic sensitivity, conventionally defined …

Rodent models of chronic intermittent hypoxia (IH) are commonly used to investigate the
pathophysiological sequelae that result from hypoxic exposure in patients experiencing …

Intermittent hypoxia (IH) is extensively applied to challenge cardiovascular and respiratory
function, and to induce physiological acclimatization. The purpose of this study was to test …

Stewart, Glenn M., Troy J. Cross, Michael J. Joyner, Steven C. Chase, Timothy Curry, Josh
Lehrer-Graiwer, Kobina Dufu, Nicholas E. Vlahakis, and Bruce D. Johnson. Impact of …

In humans exposed to 8 h of isocapnic hypoxia, there is a progressive increase in ventilation
that is associated with an increase in the ventilatory sensitivity to acute hypoxia. To …

We used two protocols to determine if hypoxic ventilatory decline (HVD) involves changes in
slope and/or intercept of the isocapnic HVR (hypoxic ventilatory response, expressed as the …

Readers are invited to give their views on this and the accompanying CrossTalk articles in
this issue by submitting a brief (250 word) comment. Comments may be submitted up to 6 …