Icotinib is as efficacious as gefitinib for brain metastasis of EGFR mutated non-small-cell lung cancer

K Liu, G Jiang, A Zhang, Z Li, J Jia - BMC cancer, 2020 - Springer
Background The prognosis of non-small-cell lung cancer (NSCLC) with brain metastases is
very poor. Currently, therapeutic methods for this patient population include whole-brain …

Effects of icotinib with and without radiation therapy on patients with EGFR mutant non-small cell lung cancer and brain metastases

Y Fan, Y Xu, L Gong, L Fang, H Lu, J Qin, N Han… - Scientific reports, 2017 - nature.com
EGFR-TKIs and radiation therapy (RT) are the principal treatment for patients with brain
metastases (BM) and EGFR mutant NSCLC. However, the optimal use of brain RT for …

PL03. 05: BRAIN: a phase III trial comparing WBI and chemotherapy with icotinib in NSCLC with brain metastases harboring EGFR mutations (CTONG 1201)

YL Wu, JJ Yang, C Zhou, J Feng, S Lu, Y Song… - Journal of Thoracic …, 2017 - jto.org
Background Non-small cell lung cancer (NSCLC) with brain metastases (M) had a poor
prognosis. Whole brain irradiation (WBI) is a standard of care for this critical medical …

Multiple treatment modalities for brain metastasis in patients with EGFR-mutant non-small-cell lung cancer

H Wang, X Yu, Y Fan, Y Jiang - OncoTargets and therapy, 2018 - Taylor & Francis
Background There are many controversies concerning the best management of epidermal
growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) patients with …

The effectiveness of EGFR-TKIs against brain metastases in EGFR mutation-positive non-small-cell lung cancer

H Bai, B Han - OncoTargets and therapy, 2017 - Taylor & Francis
Brain metastases are usual in non-small-cell lung cancer (NSCLC) with poor prognosis and
few available therapeutic options. This retrospective study aims to evaluate the efficacy of …

Gefitinib plus chemotherapy vs gefitinib alone in untreated EGFR-mutant non–small cell lung cancer in patients with brain metastases: the GAP BRAIN open-label …

X Hou, M Li, G Wu, W Feng, J Su, H Jiang… - JAMA Network …, 2023 - jamanetwork.com
Importance Use of tyrosine kinase inhibitors (TKIs) is the standard therapy for epidermal
growth factor receptor (EGFR)–mutated non–small cell lung cancer (NSCLC) with brain …

The optimal therapy strategy for epidermal growth factor receptor‐mutated non‐small cell lung cancer patients with brain metastasis: A real‐world study from Taiwan

WC Cheng, YC Shen, CR Chien, WC Liao… - Thoracic …, 2022 - Wiley Online Library
Background The treatment options for epidermal growth factor receptor (EGFR)‐mutated
non‐small cell lung cancer (NSCLC) with brain metastases (BMs) include EGFR‐tyrosine …

[HTML][HTML] Real-world data on prognostic factors for overall survival in EGFR-mutant non-small-cell lung cancer patients with brain metastases

X Yu, Y Fan - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Background: With the wide application of epidermal growth factor receptor-tyrosine kinase
inhibitors (EGFR-TKIs), the survival of EGFR-mutant non-small-cell lung cancer (NSCLC) …

Real‐world utilization of EGFR TKIs and prognostic factors for survival in EGFR‐mutated non‐small cell lung cancer patients with brain metastases

X Yu, J Sheng, G Pan, Y Fan - International Journal of Cancer, 2021 - Wiley Online Library
Brain metastases (BMs) cause morbidity and mortality in patients with non‐small cell lung
cancer (NSCLC). The optimal management of epidermal growth factor receptor (EGFR) …

EGFR-TKI therapy for patients with brain metastases from non-small-cell lung cancer: a pooled analysis of published data

Y Fan, X Xu, C Xie - OncoTargets and therapy, 2014 - Taylor & Francis
Introduction Brain metastases are one of the leading causes of death from non-small-cell
lung cancer (NSCLC). The use of epidermal growth factor receptor (EGFR) tyrosine kinase …