[HTML][HTML] Concurrent brain radiotherapy and EGFR-TKI may improve intracranial metastases control in non-small cell lung cancer and have survival benefit in patients …

Y Liu, L Deng, X Zhou, Y Gong, Y Xu, L Zhou, J Wan… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) has intracranial
activity in EGFR-mutant Non-Small Cell Lung Cancer (NSCLC). The optimal timing of brain …

[HTML][HTML] Is afatinib a treatment option for brain metastases in patients with EGFR mutation-positive non-small cell lung cancer?

S Watanabe, H Hayashi… - Annals of Translational …, 2016 - ncbi.nlm.nih.gov
Treatment for advanced non-small cell lung cancer (NSCLC) depends on the molecular
characteristics of the tumor. Mutations of the gene for the epidermal growth factor receptor …

Comparison of up-front radiotherapy and TKI with TKI alone for NSCLC with brain metastases and EGFR mutation: a meta-analysis

C Wang, X Lu, Z Lyu, N Bi, L Wang - Lung Cancer, 2018 - Elsevier
Abstract Objective About 50–70% non-small cell lung cancer (NSCLC) patients with EGFR
mutation go through brain metastases (BM). Radiotherapy is the standard treatment before …

[HTML][HTML] The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: a systematic review and meta …

WY Li, TT Zhao, HM Xu, ZN Wang, YY Xu, Y Han… - BMC cancer, 2019 - Springer
Background The brain is a common site for metastasis in non-small-cell lung cancer
(NSCLC). This study was designed to evaluate the relationship between the mutational of …

Osimertinib for EGFR‐Mutant Lung Cancer with Brain Metastases: Results from a Single‐Center Retrospective Study

L Xie, S Nagpal, HA Wakelee, G Li, SG Soltys… - The …, 2019 - academic.oup.com
Introduction Osimertinib is a third‐generation tyrosine kinase inhibitor, initially approved for
epidermal growth factor receptor (EGFR) mutant non‐small cell lung cancer (NSCLC) with …

Multidisciplinary expert opinion on the treatment consensus for patients with EGFR mutated NSCLC with brain metastases

S Ponce, J Bruna, O Juan, R López, A Navarro… - Critical reviews in …, 2019 - Elsevier
The presence of an epidermal growth factor receptor (EGFR) mutation is associated with
higher incidence of brain metastases in patients with non-small cell lung cancer (NSCLC); …

[HTML][HTML] Greater efficacy of chemotherapy plus bevacizumab compared to chemo-and targeted therapy alone on non-small cell lung cancer patients with brain …

N Tang, J Guo, Q Zhang, Y Wang, Z Wang - Oncotarget, 2016 - ncbi.nlm.nih.gov
Control of non-small-cell lung cancer (NSCLC) with brain metastasis is clinically
challenging. This study retrospectively evaluated the efficacy of different adjuvant therapies …

[HTML][HTML] Erlotinib as second-line treatment in patients with advanced non-small-cell lung cancer and asymptomatic brain metastases: a phase II study (CTONG–0803)

YL Wu, C Zhou, Y Cheng, S Lu, GY Chen, C Huang… - Annals of …, 2013 - Elsevier
Background This phase II, open-label study evaluated the efficacy and safety of erlotinib as
second-line therapy in non-small-cell lung cancer (NSCLC) patients with brain metastases …

Osimertinib early dose reduction as a risk to brain metastasis control in EGFR‐mutant non‐small cell lung cancer

T Tozuka, R Noro, A Miyanaga, S Nakamichi… - Cancer …, 2023 - Wiley Online Library
Background The epidermal growth factor receptor (EGFR) mutation is a risk factor
associated with brain metastases (BMs) in patients with non‐small cell lung cancer …

Radiological features of brain metastases from non-small cell lung cancer harboring EGFR mutation

S Takamori, G Toyokawa, M Shimokawa… - Anticancer …, 2018 - ar.iiarjournals.org
Aim: To investigate the radiological features on computed tomography (CT) of brain
metastasis (BM) from epidermal growth factor receptor (EGFR)-mutated non-small cell lung …