CCSVI-A. A call to clinicans and scientists to vocalise in an Internet age

AR Gafson, G Giovannoni - Multiple Sclerosis and Related Disorders, 2014 - Elsevier
Abstract In 2008, Paulo Zamboni pioneered the 'liberation procedure'for treating multiple
sclerosis (MS), claiming that MS is caused by an abnormality of venous drainage which he …

CCSVI deconstructed and discarded

F Barkhof, MP Wattjes - Nature Reviews Neurology, 2013 - nature.com
Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a cause of
multiple sclerosis (MS). However, two new studies found a very low overall prevalence of …

Chronic cerebrospinal venous insufficiency (CCSVI) and multiple sclerosis (MS): a critical review

C Zecca, C Gobbi - … (Formerly Current Drug Targets-CNS & …, 2011 - ingentaconnect.com
Multiple sclerosis (MS) is a chronic disease of the central nervous system with not yet
completely understood pathogenesis. The so called “chronic cerebrospinal venous …

Funding CCSVI research is/was a waste of valuable time, money and intellectual energy: yes

A Ghezzi - Multiple Sclerosis Journal, 2013 - journals.sagepub.com
In the case of CCSVI, all of these criteria are either not, or only partially, fulfilled: 5 a) the
discrepancy of results is against criterion 1; b) the lack of reproducibility against criterion 2 …

[HTML][HTML] Italian multicentre observational study of the prevalence of CCSVI in multiple sclerosis (CoSMo study): rationale, design, and methodology

G Comi, MA Battaglia, A Bertolotto, M Del Sette… - Neurological …, 2013 - Springer
Chronic cerebro-spinal venous insufficiency (CCSVI) has been proposed as a “congenital
malformation” implicated in the pathogenesis of multiple sclerosis (MS). However, numerous …

Cerebrospinal venous insufficiency and multiple sclerosis: investigating the truth

O Khan - Multiple Sclerosis Journal, 2011 - journals.sagepub.com
The hypothesis that extra-cranial venous flow abnormalities leading to a stagnant venous
return contribute to the pathogenesis of multiple sclerosis (MS) has generated passionate …

The perfect crime? CCSVI not leaving a trace in MS

CA Mayer, W Pfeilschifter, MW Lorenz… - Journal of Neurology …, 2011 - jnnp.bmj.com
Background Multiple sclerosis (MS) is a chronic, inflammatory demyelinating disease of the
central nervous system, believed to be triggered by an autoimmune reaction to myelin …

CCSVI is associated with multiple sclerosis

S Morovic, P Zamboni - Neurological research, 2012 - Taylor & Francis
Objectives: To analyze all the arguments against chronic cerebrospinal venous insufficiency
(CCSVI) as a medical entity, and its association with multiple sclerosis (MS) and to revise all …

[HTML][HTML] Chronic cerebrospinal venous insufficiency is not associated with multiple sclerosis and its severity: a blind-verified study

MA Leone, O Raymkulova, P Naldi, P Lochner… - PLoS …, 2013 - journals.plos.org
Background Chronic Cerebrospinal Venous Insufficiency (CCSVI) has been associated with
multiple sclerosis (MS) with a risk ranging from as high as two-hundred-fold to a protective …

Editorial [Hot Topic: New Avenues of Research on Multiple Sclerosis from the Perspective of Chronic Cerebrospinal Venous Insufficiency Paradigm (Guest Editor …

M Simka - Reviews on Recent Clinical Trials, 2012 - ingentaconnect.com
Multiple sclerosis (MS) is a chronic and debilitating neurological disease characterized by
multifocal areas of inflammation, demyelination and neurodegeneration within the brain and …