Betaine (N, N, N-trimethylglycine) plays key roles in mouse eggs and preimplantation
embryos first in a novel mechanism of cell volume regulation and second as a major methyl …

Betaine has important roles in preimplantation mouse embryos, including as an organic
osmolyte that functions in cell volume regulation in the early preimplantation stages and as a …

Methylation reactions, mediated by methyltransferases, are vital to many processes in cells.
DNA methylation, which epigenetically regulates gene expression, is of particular interest …

Methyltransferases are an important group of enzymes with diverse roles that include
epigenetic gene regulation. The universal donor of methyl groups for methyltransferases is S …

Abstract Betaine (N, N, N-trimethylglycine) has previously been shown to function in cell
volume homeostasis in early mouse embryos and also to be a key donor to the methyl pool …

Betaine protects early preimplantation mouse embryos against increased osmolarity in vitro,
functioning as an organic osmolyte. Betaine is effective at very low external concentrations …

Mammal embryos can be impaired by mother's excessive ethanol uptake, which induces a
higher level of reactive oxygen species (ROS) and interferes in one carbon unit metabolism …

The coupled action of the Na+/H+ exchanger NHE1 and the HCO3−/Cl− exchanger AE2
constitutes the principal mechanism for acute correction of decreased cell volume in …

Scope Betaine is widely used in animal nutrition to promote growth. Here, we aimed to
investigate whether maternal betaine supplementation during pregnancy can exert …

Betaine is reported to regulate hepatic cholesterol metabolism in mammals. Chicken eggs
contain considerable amount of betaine, yet it remains unknown whether and how betaine in …