IL-7 regulation of cytotoxic lymphocytes: pore-forming protein gene expression, interferon-γ production, and cytotoxicity of human peripheral blood lymphocyte subsets
MJ Smyth, Y Norihisa, JR Gerard, HA Young… - Cellular …, 1991 - Elsevier
The effects of IL-7 on the generation of cytolytic human peripheral blood lymphocytes (PBL)
were investigated. Induction of T-cell pore-forming protein (PFP) mRNA and cytotoxic …
were investigated. Induction of T-cell pore-forming protein (PFP) mRNA and cytotoxic …
IL-2 and IL-6 synergize to augment the pore-forming protein gene expression and cytotoxic potential of human peripheral blood T cells.
MJ Smyth, JR Ortaldo, W Bere, H Yagita… - … (Baltimore, Md.: 1950 …, 1990 - journals.aai.org
Our previous studies have demonstrated that high dose IL-2 (1000 U/ml) alone can induce
human peripheral blood T cell pore-forming protein (PFP) mRNA expression and cytotoxic …
human peripheral blood T cell pore-forming protein (PFP) mRNA expression and cytotoxic …
Interleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8+ T cells.
MJ Smyth, JR Ortaldo, YL Shinkai, H Yagita… - The Journal of …, 1990 - rupress.org
Our studies have analyzed pore-forming protein (PFP) mRNA expression in resting and
stimulated human peripheral blood CD3-large granular lymphocytes (LGL), CD3+ T cells …
stimulated human peripheral blood CD3-large granular lymphocytes (LGL), CD3+ T cells …
Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes.
MR Alderson, TW Tough, SF Ziegler… - The Journal of …, 1991 - rupress.org
Peripheral blood monocytes can be induced by stimuli such as bacterial lipopolysaccharide
(LPS) to secrete an array of cytokines. We have studied the effects of interleukin 7 (IL-7) on …
(LPS) to secrete an array of cytokines. We have studied the effects of interleukin 7 (IL-7) on …
Regulation of human cytotoxic T lymphocyte development by IL-7.
CJ Hickman, JA Crim, HS Mostowski… - Journal of immunology …, 1990 - journals.aai.org
The effects of IL-7 on the generation of human CTL in alloantigen-, virus-, and lectin-
stimulated systems were examined. Addition of IL-7 at the onset of cultures resulted in …
stimulated systems were examined. Addition of IL-7 at the onset of cultures resulted in …
Interleukin-15 induces the expression of mRNAs of cytolytic mediators and augments cytotoxic activities in primary murine lymphocytes
W Ye, JDE Young, CC Liu - Cellular immunology, 1996 - Elsevier
Interleukin-15 (IL-15) is a novel cytokine displaying biological activities that overlap those of
interleukin-2 (IL-2). Like IL-2, IL-15 has been shown to be capable of stimulating the …
interleukin-2 (IL-2). Like IL-2, IL-15 has been shown to be capable of stimulating the …
Modulation of IL‐8 receptor expression on purified human T lymphocytes is associated with changed chemotactic responses to IL‐8
Interleukin‐8 is a member of the chemokine superfamily and is a major mediator of acute
inflammation. Although IL‐8 has been reported by some laboratories also to be a …
inflammation. Although IL‐8 has been reported by some laboratories also to be a …
Recombinant IL-4 inhibits IL-6 synthesis by adherent peripheral blood cells in vitro.
R Gibbons, O Martinez, M Matli, F Heinzel… - Lymphokine …, 1990 - europepmc.org
IL-4 has been shown to participate in interregulatory networks with other cytokines including
IL-2, IFN-gamma, IL-1 beta, and TNF-alpha. The ability of recombinant IL-4 (rIL-4) to …
IL-2, IFN-gamma, IL-1 beta, and TNF-alpha. The ability of recombinant IL-4 (rIL-4) to …
IL-4 suppresses IL-1 beta, TNF-alpha and PGE2 production by human peritoneal macrophages.
PH Hart, RL Cooper, JJ Finlay-Jones - Immunology, 1991 - ncbi.nlm.nih.gov
Abstract Human interleukin-4 (IL-4) down-regulates IL-1 and tumour necrosis factor-alpha
(TNF-alpha) production by monocytes stimulated in vitro. In contrast, in studies of activation …
(TNF-alpha) production by monocytes stimulated in vitro. In contrast, in studies of activation …
IL-4 inhibits IL-2-induced tumoricidal activity and secretory functions of human monocytes. Modulation of IL-2 binding and IL-2 receptor beta gamma chain expression.
Human monocytes express functional IL-2 receptors (IL-2R) and are directly activated by IL-
2 to exert effector and secretory functions. In this study, we show that IL-4 selectively …
2 to exert effector and secretory functions. In this study, we show that IL-4 selectively …