Mesenchymal stem cells in drug/gene delivery: implications for cell therapy

SJ Greco, P Rameshwar - Therapeutic delivery, 2012 - Taylor & Francis
Stem cells have been therapeutically utilized in replacement of hematopoetic cells for
decades. This is in contrast to the recent emergence of adult stem cells as, perhaps, safe …

Neuroprotective features of mesenchymal stem cells

A Uccelli, F Benvenuto, A Laroni, D Giunti - Best practice & research …, 2011 - Elsevier
Bone marrow (BM) derived mesenchymal stem cells (MSC) differentiate into cells of the
mesodermal lineage but also, under certain experimental circumstances, into cells of the …

Clinical experience with stem cells and other cell therapies in neurological diseases

D Karussis, P Petrou, I Kassis - Journal of the neurological sciences, 2013 - Elsevier
To overcome the limited capacity of the CNS for regeneration, the theoretical alternative
would be to use stem cells for more effective management of chronic degenerative and …

Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial

A Uccelli, A Laroni, R Ali, MA Battaglia… - The Lancet …, 2021 - thelancet.com
Summary Background Mesenchymal stem cells (MSCs), also known as mesenchymal
stromal cells, have been proposed as a promising therapeutic option for people with multiple …

[图书][B] Mesenchymal stem cells: methods and protocols

DJ Prockop, DG Phinney, BA Bunnell - 2008 - Springer
For over forty years, mesenchymal stem cells (MSCs) have been scrutinized and studied,
garnering much attention due to their broad therapeutic efficacy. In Mesenchymal Stem …

A focus on allogeneic mesenchymal stromal cells as a versatile therapeutic tool for treating multiple sclerosis

A Shokati, A Naser Moghadasi, M Nikbakht… - Stem Cell Research & …, 2021 - Springer
Multiple sclerosis (MS) is a central nervous system (CNS) chronic illness with autoimmune,
inflammatory, and neurodegenerative effects characterized by neurological disorder and …

Cell-based therapies for stroke: promising solution or dead end? Mesenchymal stem cells and comorbidities in preclinical stroke research

F Laso-García, L Diekhorst… - Frontiers in …, 2019 - frontiersin.org
Stroke is a major health problem worldwide. It has been estimated that 90% of the
population attributable risk of stroke is due to risk factors such as aging, hypertension …

Cell therapy: the final frontier for treatment of neurological diseases

S Dutta, G Singh, S Sreejith, MK Mamidi… - CNS neuroscience & …, 2013 - Wiley Online Library
Neurodegenerative diseases are devastating because they cause increasing loss of
cognitive and physical functions and affect an estimated 1 billion individuals worldwide …

Clinical trials with mesenchymal stem cells: an update

T Squillaro, G Peluso, U Galderisi - Cell transplantation, 2016 - journals.sagepub.com
In the last year, the promising features of mesenchymal stem cells (MSCs), including their
regenerative properties and ability to differentiate into diverse cell lineages, have generated …

Safety and feasibility of repeated intrathecal allogeneic bone marrow‐derived mesenchymal stromal cells in patients with neurological diseases

K Pan, L Deng, P Chen, Q Peng, J Pan… - Stem cells …, 2019 - Wiley Online Library
Mesenchymal stromal cells (MSCs) have become the most commonly used adult stem cells
in regenerative medicine. Preclinical studies have shown that MSCs‐based therapy is a …