The diagnosis of malignant melanoma is sometimes challenging. Immunohistochemistry for
specific markers of melanocytic differentiation such as HMB-45 and Melan-A can be very …

Microphthalmia transcription factor (Mitf), a melanocytic nuclear protein critical for the
embryonic development and postnatal viability of melanocytes, is a master lineage regulator …

Desmoplastic/spindle cell melanoma is a rare variant of melanoma. A number of factors
complicate the diagnosis of desmoplastic/spindle cell melanoma, including the variable …

Microphthalmia transcription factor (Mitf), a protein critical for the embryonic development
and postnatal viability of melanocytes, is a master lineage regulator and modulates …

The protein encoded by the microphthalmia (mi) gene is a transcription factor essential for
the development and survival of melanocytes. Using a monoclonal antibody generated …

Malignant melanomas do not uniformly retain expression of melanocytic gene products—an
observation associated with diagnostic dilemmas. Microphthalmia transcription factor (Mitf) …

BACKGROUND The diagnosis of melanoma can be difficult because of shared
cytomorphology with other malignant neoplasms. The most commonly used melanocytic …

The transcription factor microphthalmia (MITF) is required for the formation of normal
melanocytes during embryonic development and for the expression of pigment cell-specific …

Microphthalmia transcription factor (Mitf) is a nuclear protein involved in the development of
melanocytes and the regulation of melanin synthesis. Recent studies have suggested that …

The microphthalmia transcription factor MITF plays a pivotal role in the development and
differentiation of melanocytes. The purpose of this work was to investigate the expression …