Clinical pharmacology of midazolam in neonates and children: effect of disease—a review

GM Pacifici - International journal of pediatrics, 2014 - Wiley Online Library
Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In
healthy neonates the half‐life (t1/2) and the clearance (Cl) are 3.3‐fold longer and 3.7‐fold …

Clinical pharmacology of midazolam in infants and children

JL Blumer - Clinical pharmacokinetics, 1998 - Springer
Midazolam is a parenteral benzodiazepine with sedative, amnesic, anxiolytic, muscle
relaxant and anticonvulsant properties. The drug exerts its clinical effect by binding to a …

Pharmacokinetics of midazolam in critically ill neonates

E Jacqz-Aigrain, C Wood, I Robieux - European journal of clinical …, 1990 - Springer
Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and
children. An IV bolus of midazolam 0.2 mg· kg− 1 was administered to 10 critically ill …

Pharmacokinetics of midazolam during continuous infusion in critically ill neonates

E Jacqz-Aigrain, P Daoud, P Burtin, S Maherzi… - European journal of …, 1992 - Springer
Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and
children. An IV bolus (0.2 mg· kg− 1) immediately followed by continuous infusion of 0.06 …

The use of midazolam in the preterm neonate

J van den Anker, P Sauer - European journal of pediatrics, 1992 - repub.eur.nl
Sir: Numerous recent reports have demonstrated the occurrence of pain and stress and their
many effects in critically ill neonates. They emphasize the importance of analgesia and …

Haemodynamic responses and population pharmacokinetics of midazolam following administration to ventilated, preterm neonates

GJ Harte, PH Gray, TC Lee, PA Steer… - Journal of paediatrics …, 1997 - Wiley Online Library
Objective: To evaluate the effects of intravenous midazolam on haemodynamic variables
and cerebral blood flow velocity (CBFV) and to determine the pharmacokinetics using a …

Pharmacodynamics of intravenous and oral midazolam in preterm infants

SN de Wildt, GL Kearns, SD Sie, WCJ Hop… - Clinical drug …, 2003 - Springer
Objective The aim of this study was to evaluate the pharmacodynamics and safety of
midazolam after intravenous infusion or oral administration in preterm infants. Methods] …

Population pharmacokinetics of midazolam in neonates

P Burtin, E Jacqz‐Aigrain, P Girard… - Clinical …, 1994 - Wiley Online Library
Objective To describe the pharmacokinetics of midazolam, a water‐soluble benzodiazepine
with a short half‐life, in critically ill neonates. Hypothesis Midazolam clearance is reduced in …

Pharmacokinetics and metabolism of oral midazolam in preterm infants

SN De Wildt, GL Kearns, WCJ Hop… - British journal of …, 2002 - Wiley Online Library
Aims To characterize the pharmacokinetics and metabolism of oral midazolam in 15 preterm
infants. Methods After an oral dose (0.1 mg kg− 1), blood was drawn up to 24 h after …

The pharmacokinetics of midazolam in paediatric patients

K Payne, FJ Mattheyse, D Liebenberg… - European journal of …, 1989 - Springer
A serum concentration profile study on midazolam in children was done. Fifty six children
aged 3–10 years took part. The routes investigated were intravenous, intramuscular, rectal …