Binding of two different antidepressant drugs,[3H] paroxetine and [3H] imipramine in 30 rat
brain regions was visualized, corn-pared and quantified by means of autoradiography and …

Abstract Langer, Salomon Z. and Schoemaker, Hans: Effects of antidepressants on
monoamine transporters. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1988, 12: 193 …

Abstract [3H]-Imipramine and [3H]-paroxetine label with high affinity a site which is
associated with the serotonergic transporter in brain and platelets. The pharmacological …

Abstract [3 H] Imipramine and [3 H] paroxetine were used to label sites associated with
serotonin uptake mechanisms in post-mortem brain tissue from control subjects. The …

Antidepressant agents with properties to inhibit 5-hydroxytryptamine (5-HT, serotonin)
uptake in brain tissue and platelets bind with high affinities to neuronal and platelet …

• The high-affinity tritiated (3 H) imipramine binding sites are functionally (and perhaps
structurally) associated with the presynaptic neuronal and platelet uptake sites for serotonin …

Previous studies have demonstrated that [3H] paroxetine and [3H] cyanoimipramine ([3H]
CN-IMI) are highly selective ligands for the serotonin (5-HT) transporter. Using membrane …

The characteristics of the binding of [3 H] paroxetine, a selective serotonin (5-HT) uptake
blocker, were investigated in human brain. The K d value was 0.23±0.07 nM, and the B max …

Recent studies have demonstrated the presence of high affinity binding sites for [3 H]
imipramine in membrane preparations derived from rat brain, human platelet, and human …

The binding of the 5‐hydroxytryptamine (5‐HT, serotonin) uptake inhibitor [3H] paroxetine to
rat cortical homogenates has been characterized. The effect of tissue concentration was …