It is frequently assumed that DNA-damaging agents are carcinogenic because they induce
mutations. However, another strong possibility is that the damage leads to heritable changes …

The regulation of gene transcription is not simply dependent on the presence or absence of
DNA-binding transcription factors that turn genes on or off, but also involves processes …

Cellular differentiation involves the activation of a specific set of genes as well as the
suppression of those genes associated with the differentiation of other cell types …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

Two human genetic diseases have recently been shown to be due to mutations in genes
encoding proteins involved in DNA methylation. The phenotypes of these two diseases are …

A large number of studies have documented the methylation patterns of individual genes
and repeated sequences in different tissues of various mammalian species. This has …

Cancer is often viewed as a genetic process in which the developing cancer cell acquires
successive mutational lesions that each provide the cell with a growth or survival advantage …

An obstacle to progress in understanding eukaryotic DNA methylation has been the lack of a
good genetic systemthe most favorable eukaryotes for genetic analysis (yeasts …

The biological significance of DNA methylation has been the subject of a number of
speculations and recent reviews [1-3]. Accepted facts are that the overall level of methylation …