In addition to the four bases incorporated into DNA during semiconservative replication
there is a variable number of other bases present in DNA in small amounts. These arise by …

Epigenetic modifications of DNA such as methylation are important for genome function
during development and in adults. DNA methylation has central importance for genomic …

Site-specific methylation of the human c-myc oncogene was investigated in a set of cultured
human tumor cell lines and normal human fibroblast strains. As previously reported, all of …

The functional impact of aberrant DNA methylation and the widespread alterations in DNA
methylation in cancer development have led to the development of a variety of methods to …

DNA methylation has the ability to repress transcription; in addition, the pattern of
methylation can be stably inherited during successive cell divisions [1]. These two features …

Objective To provide an introduction to the concept of DNA methylation and its function in
normal cells, and to explain the possible mechanisms as to how abnormalities in this …

Cancer can be defined in many different ways, depending on the area in which the disease
is studied, and it can be understood to encompass a group of about 100 different and …

Next year will mark 20 years since I developed a Southern blot showing altered DNA
methylation in cancer. This discovery (1) was met with some skepticism, primarily because it …