Renal cystic diseases constitute the most common genetic cause for end-stage renal
disease in children and young adults. Recently, there has been rapid progress regarding the …

Until recently, inherited renal diseases such as renal cystic disease (RCD) were
characterized solely by a description of disease symptoms and the natural progression of …

Inherited cystic diseases of the kidneys are some of the most significant monogenic causes
of renal disorders causing significant morbidity and mortality in both the pediatric and adult …

Human cystic kidney diseases comprise a large group of congenital and acquired disorders,
many of which have a defined genetic basis. In none of these diseases do we fully …

Renal cystic diseases in adults are a heterogeneous group of disorders characterized by the
presence of multiple cysts in the kidneys. These diseases may be categorized as hereditary …

Renal cystic disease comprises a wide group of disorders which may be congenital,
acquired, sporadic, or genetically determined. All of these disorders have in common the …

We are beginning to understand the underlying molecular pathology of inherited renal cystic
disease. The development of techniques for manipulating large DNA molecules, combined …

Clinical presentation, site of the lesions, etiology and pathogenesis, and prognosis are all
highly variable across the broad spectrum of renal cystic diseases. Perhaps the most …

The term cystic diseases of the kidney includes a large number of sporadic and genetically
determined congenital, developmental, or acquired conditions that have in common the …

Context.—Renal cystic diseases and congenital abnormalities of the kidney and urinary tract
comprise a heterogeneous group of lesions whose pathogenesis has eluded physicians for …