Peptides with opioid activity are found in pepsin hydrolysates of wheat gluten and alpha-
casein. The opioid activity of these peptides was demonstrated by use of the following …

Spyros Loukas, Dido Varoucha, Christine Zioudrou,* Richard A. Streaty, and Werner A. Klee
abstract: Exorphins, peptides with opioid activity, have previously been isolated from pepsin …

Endogenous analgesic mechanisms were recognized and utilized in early times when pain
was treated with acupuncture or other types of" counter-irritation"(I) using chemical irritants …

A novel opioid peptide, Tyr‐Pro‐Ile‐Ser‐Leu, was isolated from the pepsin‐trypsin‐
chymotrypsin digest of wheat gluten. Its IC50 values were 40 μM and 13.5 μM in the GPI and …

Opioid peptides were assayed by inhibition of 3H-naloxone and 3H-leu-enkephalin binding
in brain homogenates and by depression of contractions of the guinea pig ileum and mouse …

The purification and properties of a peptide of low molecular weight (800–1200) which has
been extracted from the pig brain is described. This substance acts as an agonist at opiate …

This review was presented as an overview at the meeting of the American Society for
Pharmacology and Experimental Therapeutics in Portland, Oregon, in August, 1979. The …

MATERIALS AND METHODS Peptides were synthesized by a solid-phase method on
chloromethyl resin. 8) Peptide amides were synthesized on benzhydrylamine resin. 9) t …

Striatal extracts of guinea pigs, rats, and cattle were found to contain two large proteins
(greater than 40,000 and greater than 100,000 daltons) that on treatment with trypsin yield …

Opioid peptides are endogenous or synthetic peptides, with a spectrum of pharmacological
activity similar to that of morphine and other narcotic agonist drugs. The designation opioid …