Complex traits, including those involved in diet-related diseases, are determined by multiple
genes and environmental influences. Factors influencing the development of complex traits …

The environment encountered in fetal and neonatal life exerts a profound influence on
physiological function and risk of disease in adult life. Epidemiological evidence suggests …

The research field of fetal programming has developed tremendously over the years and
increasing knowledge suggests that both maternal and paternal unbalanced diet can have …

The risk for non-communicable diseases in adulthood can be programmed by early nutrition.
This programming is mediated by changes in expression of key genes in various metabolic …

Whilst the primary DNA sequence sets the limits of potential gene expression, the pattern of
gene expression in a given cell under particular circumstances is determined by several …

Nutrition plays a key role in many aspects of health and dietary imbalances are major
determinants of chronic diseases including cardiovascular disease, obesity, diabetes and …

Evidence is growing for the long-term effects of environmental factors during early-life on
later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene …

Epigenetic marking on genes can determine whether or not genes are expressed.
Epigenetic regulation is mediated by the addition of methyl groups to DNA cytosine bases, of …

Increasing epidemiological evidence suggests that maternal nutrition and environmental
exposure early in development play an important role in susceptibility to disease in later life …

Nutrition is the major intrauterine environmental factor that alters expression of the fetal
genome and may have lifelong consequences. This phenomenon, termed “fetal …