An overview of the development of combined oral contraceptives containing estradiol: focus on estradiol valerate/dienogest
F Fruzzetti, F Trémollieres, J Bitzer - Gynecological Endocrinology, 2012 - Taylor & Francis
Natural estrogens such as estradiol (E2) or its valerate ester (E2V) offer an alternative to
ethinyl estradiol (EE). E2-containing combined oral contraceptives (COCs) have …
ethinyl estradiol (EE). E2-containing combined oral contraceptives (COCs) have …
Review of clinical experience with estradiol in combined oral contraceptives
F Fruzzetti, J Bitzer - Contraception, 2010 - Elsevier
Previous attempts to replace ethinylestradiol (EE) with 17β-estradiol (E2) in combined oral
contraceptives (COCs) have proved unsatisfactory in terms of bleeding outcomes. A review …
contraceptives (COCs) have proved unsatisfactory in terms of bleeding outcomes. A review …
Estradiol valerate/dienogest: a novel combined oral contraceptive
LM Borgelt, CW Martell - Clinical therapeutics, 2012 - Elsevier
BACKGROUND: Estradiol valerate/dienogest (E2V/DNG) is a combined oral contraceptive
(COC) with 2 new hormonal entities and a unique 4-phasic dosing regimen indicated for …
(COC) with 2 new hormonal entities and a unique 4-phasic dosing regimen indicated for …
Estradiol valerate/dienogest: a novel oral contraceptive
KL Whalen, R Rose - Annals of Pharmacotherapy, 2011 - journals.sagepub.com
Objective: To review the pharmacology, pharmacokinetics, efficacy, and safety of the new
oral contraceptive estradiol valerate/dienogest. Data Sources: Searches of PubMed (1966 …
oral contraceptive estradiol valerate/dienogest. Data Sources: Searches of PubMed (1966 …
Ovulation inhibition with four variations of a four-phasic estradiol valerate/dienogest combined oral contraceptive: results of two prospective, randomized, open-label …
J Endrikat, S Parke, D Trummer, W Schmidt, I Duijkers… - Contraception, 2008 - Elsevier
BACKGROUND: Attempts to improve the tolerability of combined oral contraceptives (COCs)
have included the substitution of ethinylestradiol (EE) with 17β-estradiol (E2). However, this …
have included the substitution of ethinylestradiol (EE) with 17β-estradiol (E2). However, this …
Estradiol valerate/dienogest: in oral contraception
SM Hoy, LJ Scott - Drugs, 2009 - Springer
Abstract▴ Estradiol valerate/dienogest is an oral contraceptive for women that combines the
natural estrogen estradiol with the 19-nortestosterone derivative dienogest in a four-phasic …
natural estrogen estradiol with the 19-nortestosterone derivative dienogest in a four-phasic …
Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment
FZ Stanczyk, DF Archer, BR Bhavnani - Contraception, 2013 - Elsevier
The need to seek improved combined oral contraceptive (COC) efficacy, with fewer health
risks and better acceptability, has been ongoing since the introduction of COCs more than …
risks and better acceptability, has been ongoing since the introduction of COCs more than …
Efficacy and safety of a combined oral contraceptive containing estradiol valerate/dienogest: results from a clinical study conducted in North America
A Nelson, S Parke, U Mellinger… - Journal of Women's …, 2014 - liebertpub.com
Background: This study investigated the efficacy and safety of a combined oral contraceptive
(COC) containing estradiol valerate/dienogest (E2V/DNG). Methods: This was a multicenter …
(COC) containing estradiol valerate/dienogest (E2V/DNG). Methods: This was a multicenter …
[PDF][PDF] Progestogens in combined oral contraceptives for contraception
N Maitra, R Kulier, KW Bloemenkamp… - … Database Syst Rev, 2004 - researchgate.net
Progestogens in combined oral contraceptives for contraception Page 1 Progestogens in
combined oral contraceptives for contraception (Review) Maitra NN, Kulier R, Bloemenkamp K …
combined oral contraceptives for contraception (Review) Maitra NN, Kulier R, Bloemenkamp K …
Noncontraceptive benefits of the estradiol valerate/dienogest combined oral contraceptive: a review of the literature
Combined oral contraceptives formulated to include estradiol (E2) have recently become
available for the indication of pregnancy prevention. A combined estradiol valerate and …
available for the indication of pregnancy prevention. A combined estradiol valerate and …