The role of long-acting bronchodilators in the management of stable COPD

DP Tashkin, CB Cooper - Chest, 2004 - Elsevier
Bronchodilators form the foundation of symptomatic treatment of COPD. Several long-acting
bronchodilators are now available for use in COPD, but publications of large-scale studies of …

The bronchodilator response to salmeterol is maintained with regular, long-term use in patients with COPD

NA Hanania, C Kalberg, J Yates, A Emmett… - Pulmonary …, 2005 - Elsevier
Long-acting beta2-agonists (LABAs) are recommended in the management of patients with
chronic obstructive pulmonary disease (COPD). Previous studies have demonstrated that …

Early onset of effect of salmeterol and fluticasone propionate in chronic obstructive pulmonary disease

J Vestbo, R Pauwels, JA Anderson, P Jones… - Thorax, 2005 - thorax.bmj.com
Background: Combined treatment with inhaled corticosteroids and long acting β2 agonists is
approved for the treatment of chronic obstructive pulmonary disease (COPD), but little is …

Rapid onset of bronchodilation in COPD: a placebo-controlled study comparing formoterol (Foradil® AerolizerTM) with salbutamol (VentodiskTM)

D Benhamou, A Cuvelier, JF Muir, V Leclerc… - Respiratory …, 2001 - Elsevier
Formoterol fumarate is a β2-agonist bronchodilator that combines a fast onset of action with
a long duration of action. Its fast onset of action is well documented in asthma but has not …

In patients with COPD, treatment with a combination of formoterol and ipratropium is more effective than a combination of salbutamol and ipratropium: a 3-week …

AD D'Urzo, MC De Salvo, A Ramirez-Rivera, J Almeida… - Chest, 2001 - Elsevier
Study objectives: To compare the efficacy of adding formoterol or salbutamol to regular
ipratropium bromide treatment in COPD patients whose conditions were suboptimally …

Faster Onset of Bronchodilation with Formoterol than with Salmeterol in Patients with Stable, Moderate‐Severe Copd: Results of a Randomized, Double‐Blind Clinical …

J Kottakis, GD Cioppa, J Creemers… - Canadian respiratory …, 2002 - Wiley Online Library
OBJECTIVES: To compare the onset and magnitude of bronchodilation after dry powder
inhalations of formoterol fumarate (Foradil Aerolizer) versus salmeterol xinofoate (Serevent …

Fast onset of effect of budesonide/formoterol versus salmeterol/fluticasone and salbutamol in patients with chronic obstructive pulmonary disease and reversible …

A Lindberg, Z Szalai, T Pullerits, E Radeczky - Respirology, 2007 - Wiley Online Library
Background and objectives: Data on the onset of action of COPD medications are lacking.
This study compared the onset of bronchodilation following different inhaled therapies in …

Incremental benefit of adding oxitropium bromide to formoterol in patients with stable COPD

M Cazzola, F Di Perna, C Califano… - Pulmonary …, 1999 - Elsevier
The effects of the long-acting β2-agonist formoterol, the anticholinergic drug oxitropium
bromide, and their combination were compared in 16 patients with partially reversible stable …

Onset of action of single doses of formoterol administered via Turbuhaler in patients with stable COPD

M Cazzola, S Centanni, C Regorda, F di Marco… - Pulmonary …, 2001 - Elsevier
We studied 16 patients with stable COPD in a double blind, double dummy, placebo-
controlled, within patient study to see if formoterol could be used as a rescue drug. We …

A pilot study to assess the effects of combining fluticasone propionate/salmeterol and tiotropium on the airflow obstruction of patients with severe-to-very severe COPD

M Cazzola, F Andò, P Santus, P Ruggeri… - Pulmonary …, 2007 - Elsevier
The aim of this pilot study was to explore the relative efficacy in terms of improvement in
symptoms and lung function of combining fluticasone propionate/salmeterol combination …