Morphine (1) continues to occupy a position of unique clinical importance in medicine, its
wide prescription for the treatment of severe pain and for relief of suffering in the terminally ill …

Abstract Asymmetric total synthesis of (−)‐morphine has been accomplished in 18 steps
from commercially available 7‐methoxy‐2‐tetralone. Our synthesis features a simple …

The preparation of the diastereomerically pure β-tetralone ketal 4 is reported. Intramolecular
alkylidene C− H insertion followed by hydrolysis of 4 proceeded to give the enantiomerically …

Goto's group. 4a~ c To define morphine's interaction with opiate receptors more clearly, 5 we
wanted to prepare large quantities of unnatural enantiomer 10 and several of its congeners …

This feature article encapsulates the senior author's long-standing interests in opiate
chemistry and attempts to place it within an historical context and against the backdrop of …

Diastereoselective synthesis of racemic 3, 4-dimethoxy-7-morphinanone from racemic 2-(2,
3-dimethoxyphenyl) cyclohexen-1-ol has been achieved. The relative structure has been …

The synthesis of racemic morphine from 2-allylcyclohexane-l, 3-dione and isovanillin is
described. Sir: As the cornerstone strategy in our approach to the morphine ring system we …

A concise enantio-and diastereocontrolled route to (−)-morphine has been developed
starting from a bicyclo [3.2. 1] octenone chiral building block through an acid-catalyzed …

Results Phenol Synthesis. The tetrasubstituted phenols used throughout this study were
synthesized from commercially available isovanillin (Scheme III). 8 Bromination of iso …

The synthesis of the narcotic analgesic dextrorphan (4) and its desoxy derivative has been
accomplished via an asymmetric alkylation of octahydroisoquinoline 10. The latter …