Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …

ABSTRACT NF‐E2‐related factor 2 (Nrf2) is a basic leucine zipper transcription factor that
binds to the promoter sequence “antioxidant responsive element (ARE)” leading to …

Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that regulates Antioxidant
Response Element (ARE)-mediated transcription of a plethora of antioxidant and protective …

Oxidative stress plays an important part in the pathogenesis of a variety of diseases. The
ability to mount an efficient response against the continuous threat posed by exogenous and …

Antioxidant response element (ARE)-mediated expression and coordinated induction of
antioxidant enzymes is a critical mechanism of protection against chemically induced …

Human exposures to environmental toxicants have been associated with etiology of many
diseases including inflammation, cancer, and cardiovascular and neurodegenerative …

Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …

Eukaryotic cells counteract oxidative and other environmental stress through the activation
of Nrf2, the transcription factor that controls the expression of a host of protective enzymes by …

To maintain intracellular redox homeostasis, genes encoding many antioxidants and
detoxification enzymes are transcriptionally upregulated upon deleterious oxidative stress …

Animals have evolved defense systems for surviving in a chemically diverse environment.
Such systems should demonstrate plasticity, such as adaptive immunity, enabling a …