Infertility is a common problem affecting one in six couples, and in 30% of infertile couples,
the male factor is a major cause due to defective sperm quality. P-glycoprotein (P-gp), a …

Infertility affects 1 in 6 couples and approximately 1 in 25 men. Male factor infertility is a
major cause of spermatogenic anomalies, the causes of which are largely unknown …

The present meta-analysis is performed to determine the association of C1236T and
C3435T polymorphisms in the MDR1 gene. Google Scholar, PubMed, and Science Direct …

The three functional single-nucleotide polymorphisms (SNPs) of the MDR1 gene, C1236T,
G2677T/A, and C3435T, exhibit an interpopulation difference. In this study, we analyzed the …

Aims The aim of the study was to determine whether a correlation exists between MDR1
(ABCB1) gene polymorphisms at positions 3435 (C3435T) and 2677 (G2677T (A)) and the …

The genetic variability, haplotype profile and ethnic differences of MDR1 polymorphisms in
healthy Roma and Hungarian populations were analyzed and the results were compared …

ABSTRACT MDR1 gene encodes for P glycoprotein (P-gp), which plays an important role in
bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three …

Pharmacogenomics is a rapidly developing field of biomedical research, which investigates
phenotypic and pharmacodynamic consequences of the genetic variations among …

BACKGROUND: The CYP1A1 gene is a polymorphic gene and encodes for the CYP1A1
enzyme that catalyzes the bioactivation of polycyclic aromatic hydrocarbons (PAHs). PAHs …

The MDR1 gene product P-glycoprotein in the human placenta is important for protecting the
fetus from unintended, harmful drug exposure, but also for limiting the access of therapeutic …