HL-60 cells that stably express transfected wild-type (wt) p53 were used to determine
whether restoration of wt p53 increased the chemosensitivity of cells that normally lack p53 …

The relationship between chemosensitivity and p53 is currently considered from two
mutually exclusive points of view:(1) wt p53 increases chemosensitivity due to apoptosis and …

The spectrum of p53 mutations differs among human cancer types. We have hypothesized
that the p53 mutational spectrum observed in particular tumor types reflects the functional …

The possibility that appropriately designed chemotherapy could act selectively against p53-
defective tumor cells was explored in MCF-7 human breast cancer cells. These cells were …

The introduction of exogenous wild-type p53 into human cancer cells bearing p53 mutation
does not necessarily result in inhibition of tumor growth. We have demonstrated this in MDA …

A human osteosarcoma cell line, Saos-2, which is devoid of endogenous p53 gene, and
clones of Saos-2 cells, which were transfected with wild type p53 or mutant p53 genes …

Mutational loss of p53 tumor suppressor functions has been observed in a wide range of
neoplasms and was associated with either enhanced or decreased chemosensitivity of …

Wild-type p53 (wt-p53) negatively controls cell cycle progression after cellular stress
mediating either a temporary growth arrest or apoptosis, depending on the cell type and …

Biochemical and functional properties of wild-type (wt) and mutant p53 were studied under
the same cellular environment by transient transfection. Exogenous wt p53 expressed in …

We have examined the effects of conditionally expressing wild-type p53 activity in HT29
cells on DNA damage and cytotoxicity caused by exposure to fluorodeoxyuridine (FdUrd) …