Noninferiority trial design and analyses are commonly used to establish the effectiveness of
a new antimicrobial drug for treatment of serious infections such as complicated urinary tract …

Background The efficacies and adverse effects of different antibiotics for uncomplicated
urinary tract infections (UTIs) have been studied by standard meta-analytic methods using …

Objective To assess the clinical efficacy and safety of novel antibiotics for complicated
urinary tract infections (cUTIs). Methods Three electronic databases (Medline, Embase and …

Abstract Background Current US Food and Drug Administration guidance recommends that
the primary endpoint for complicated urinary tract infection clinical trials be a composite of …

The aim of this study was to investigate the urinary bactericidal titers (UBTs) and 24-h area
under the UBT-versus-time curve (AUBT) of intravenous doripenem (500 mg every 8 h …

Background: Complicated urinary tract infections (cUTI) are universal reasons for
hospitalization, and highly likely to develop into sepsis or septic shock. Carbapenem …

Comparative Effectiveness of Different Oral Antibiotics Regi... : Medicine Comparative
Effectiveness of Different Oral Antibiotics Regimens for Treatment of Urinary Tract Infection in …

Introduction Complicated urinary tract infections (cUTIs) are associated with poor prognosis.
The widespread infection of multidrug-resistant Gram-negative uropathogens such as …

Objectives Active-comparator, non-inferiority study designs are used in uncomplicated
urinary tract infection (uUTI) to establish the efficacy of a new antibacterial, given the …

Background Traditional end points used in registrational randomized, controlled trials
(RCTs) often do not allow for complete interpretation of the full range of potential clinical …