Chemopreventive strategies for colorectal cancer (CRC) have been extensively studied to
prevent the recurrence of adenomas and/or delay their development in the gastrointestinal …

Over the past 20 years exciting developments in clinical and basic research have opened up
the possibility of NSAID-induced colorectal cancer chemoprevention. In particular …

OBJECTIVE: To discuss the role of nonsteroidal antiinflammatory drugs (NSAIDs) in the
chemoprevention of colorectal cancer. DATA SOURCES: A MEDLINE search (1966–May …

This article discusses the merits and limits of nonsteroidal antiinflammatory drugs (NSAIDs),
including cyclooxygenase (COX)-2 inhibitors, for colorectal cancer prevention. The …

Colorectal cancer is a major cause of morbidity and mortality accounting for an estimated
550,000 deaths annually worldwide. Colonic neoplasia develops in a stepwise fashion …

Chemoprevention refers to the use of natural or synthetic agents to reverse, suppress, or
prevent progression or recurrence of cancer. Colorectal cancers result from complex …

The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …

Colorectal cancer is the most common cancer in Western countries and the second leading
cause of cancerrelated death. Sporadic lesions represent 75-80% of all colorectal cancer …

Chemoprevention of colorectal cancer is a promising science that has particular importance
due to the limited success of current treatments for most advanced common malignancies …

Colorectal cancer is an excellent model for studying cancer prevention by means of
secondary (eg, polypectomy to remove a precursor adenoma) and primary …