COX-2 active agents in the chemoprevention of colorectal cancer

S Kraus, I Naumov, N Arber - … of Colorectal Neoplasia: Emerging Role of …, 2013 - Springer
Chemopreventive strategies for colorectal cancer (CRC) have been extensively studied to
prevent the recurrence of adenomas and/or delay their development in the gastrointestinal …

Chemoprevention of colorectal cancer by non-steroidal anti-inflammatory drugs.

PJ Bus, HW Verspaget, CB Lamers… - Scandinavian Journal of …, 2000 - europepmc.org
Over the past 20 years exciting developments in clinical and basic research have opened up
the possibility of NSAID-induced colorectal cancer chemoprevention. In particular …

Use of NSAIDs for the chemoprevention of colorectal cancer

JM Herendeen, C Lindley - Annals of Pharmacotherapy, 2003 - journals.sagepub.com
OBJECTIVE: To discuss the role of nonsteroidal antiinflammatory drugs (NSAIDs) in the
chemoprevention of colorectal cancer. DATA SOURCES: A MEDLINE search (1966–May …

NSAIDs and colorectal cancer prevention

T Iwama - Journal of gastroenterology, 2009 - Springer
This article discusses the merits and limits of nonsteroidal antiinflammatory drugs (NSAIDs),
including cyclooxygenase (COX)-2 inhibitors, for colorectal cancer prevention. The …

Prevention of colorectal cancer through the use of COX-2 selective inhibitors

RM Peek - Cancer chemotherapy and pharmacology, 2004 - Springer
Colorectal cancer is a major cause of morbidity and mortality accounting for an estimated
550,000 deaths annually worldwide. Colonic neoplasia develops in a stepwise fashion …

Prevention of colorectal cancer: Tumor progression, chemoprevention, and COX–2 inhibition

RS Bresalier - Gastroenterology, 2000 - Elsevier
Chemoprevention refers to the use of natural or synthetic agents to reverse, suppress, or
prevent progression or recurrence of cancer. Colorectal cancers result from complex …

COX-2 inhibition as a tool to treat and prevent colorectal cancer

JB Tuynman, MP Peppelenbosch, DJ Richel - Critical reviews in oncology …, 2004 - Elsevier
The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …

Mechanisms of colon cancer prevention with and beyond COX-2 inhibition

F Rodriguez-Moranta, A Castells - Current topics in medicinal …, 2005 - ingentaconnect.com
Colorectal cancer is the most common cancer in Western countries and the second leading
cause of cancerrelated death. Sporadic lesions represent 75-80% of all colorectal cancer …

Role of cyclooxygenase-2 in pathogenesis and prevention of colorectal cancer

E Hahn, S Kraus, N Arber - Digestive Diseases, 2010 - karger.com
Chemoprevention of colorectal cancer is a promising science that has particular importance
due to the limited success of current treatments for most advanced common malignancies …

COX-2 inhibition in clinical cancer prevention.

PM Lynch - Oncology (Williston Park, NY), 2001 - europepmc.org
Colorectal cancer is an excellent model for studying cancer prevention by means of
secondary (eg, polypectomy to remove a precursor adenoma) and primary …