Tumor-associated neoangiogenesis and suppression of antitumor immunity are hallmarks of
tumor development and progression. Death receptor 6 (DR6) has been reported to be …

Background The Death Receptor 6 (DR6) protein is elevated in the serum of ovarian cancer
patients. We tested DR6 serum protein levels as a diagnostic/predictive biomarker in several …

BACKGROUND. Death receptors mediate both apoptosis and survival in cancer cells. The
authors analyzed death receptor expression in metastatic ovarian carcinoma. METHODS …

Death receptor 5 (DR5) can inhibit malignant proliferation via tumor necrosis factor‐related
apoptosis‐inducing ligand (TRAIL)‐induced apoptosis in many cancers. Here we examined …

Abstract Although death receptor 6 (DR6) is aberrantly expressed in certain cancer cell
lines, its function, signaling pathway and potential clinical significance in tumor progression …

One of the most recently identified members of the tumor necrosis factor receptor family,
death receptor-6 (DR6), has been shown to mediate apoptosis following overexpression in …

OBJECTIVES.: The purpose of this study was to evaluate the cytotoxicity of a death receptor
5 (DR5) targeting monoclonal antibody (TRA-8) in primary ovarian cancer specimens …

Abstract Death receptor-3 (DR3) plays controversial roles in cancer. Currently, DR3 is
known to be a functional receptor of vascular endothelial growth inhibitor (VEGI). The role of …

Objectives. Defects in the apoptotic pathway are a general cause for drug resistance.
Chemotherapy in combination with tumor necrosis factor-related apoptosis-inducing ligand …

Background/Aim: Death receptor 6 (DR6) is a member of the tumor necrosis factor receptor
superfamily. The expression of DR6 is elevated in different kinds of tumors including …