Neuroblastoma× glioma hybrid cells synthesize enkephalin‐like opioid peptides

T Glaser, K Hübner, B Hamprecht - Journal of Neurochemistry, 1982 - Wiley Online Library
Partially purified extracts from neuroblastoma× glioma hybrid cells 108CC15 inhibit, like
opioids, the prostaglandin E1‐evoked formation of cyclic AMP in a dose‐dependent manner …

Antinociception induced by electrical stimulation of spinally projecting noradrenergic neurons in the A7 catecholamine cell group of the rat

DC Yeomans, FM Clark, JA Paice, HK Proudfit - Pain, 1992 - journals.lww.com
Recent anatomical evidence indicates that the pontine A7 catecholamine cell group
provides the major noradrenergic innervation of the spinal cord dorsal horn (laminae I-IV) …

Transgenic mice possessing increased numbers of nociceptors do not exhibit increased behavioral sensitivity in models of inflammatory and neuropathic pain

M Zwick, DC Molliver, J Lindsay, CA Fairbanks… - Pain, 2003 - Elsevier
At least two classes of nociceptors can be distinguished based on their growth factor
requirements: glial cell-line derived neurotrophic factor (GDNF)-and nerve growth factor …

Constitutive desensitization of opioid receptors in peripheral sensory neurons

LC Sullivan, TS Chavera, RJ Jamshidi, KA Berg… - … of Pharmacology and …, 2016 - ASPET
Opioid receptors expressed by peripheral pain-sensing neurons are functionally inactive for
antinociceptive signaling under most basal conditions; however, tissue damage or exposure …

Effects of iontophoretically released peptides on primate spinothalamic tract cells

WS Willcockson, JM Chung, Y Hori… - Journal of …, 1984 - Soc Neuroscience
The peptides substance P (SP), methionine-enkephalin (M-ENK), leucine-enkephalin (L-
ENK), and cholecystokinin (CCK) were released iontophoretically near spinothalamic tract …

Alterations in nociception following adrenal medullary transplants into the rat periaqueductal gray

J Sagen, GD Pappas, MJ Perlow - Experimental brain research, 1987 - Springer
Adrenal medullary chromaffin cells were transplanted to the midbrain periaqueductal gray, a
region known to play a primary role in the modulation of nociception. Chromaffin cells were …

[HTML][HTML] Interleukin-6 induces nascent protein synthesis in human dorsal root ganglion nociceptors primarily via MNK-eIF4E signaling

ME Mitchell, G Torrijos, LF Cook, JM Mwirigi, L He… - Neurobiology of Pain, 2024 - Elsevier
Plasticity of dorsal root ganglion (DRG) nociceptors in the peripheral nervous system
requires new protein synthesis. This plasticity is believed to be responsible for the …

Enkephalin antinociception in mice is mediated by δ1-and δ2-opioid receptors in the brain and spinal cord, respectively

AE Takemori, PS Portoghese - European journal of pharmacology, 1993 - Elsevier
Pharmacological evidence for the existence of δ-opioid receptor subtypes has been
reported. This study was conducted to determine which type of δ-opioid receptors was …

Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain

I Décosterd, E Buchser, N Gilliard, J Saydoff, AD Zurn… - Pain, 1998 - Elsevier
Intrathecal implants of adrenal chromaffin cells are known to release analgesic substances
such as catecholamines and opioid peptides. In the present study, bovine chromaffin cells …

Selective attenuation of μ-opioid receptor-mediated effects in rat sensory neurons by intrathecal administration of antisense oligodeoxynucleotides

SG Khasar, MS Gold, S Dastmalchi, JD Levine - Neuroscience letters, 1996 - Elsevier
To test the hypothesis that the expression of specific proteins on peripheral terminals of
primary afferents can be attenuated by intrathecal administration of antisense …