Studies have demonstrated that the L-arginine/NO/cGMP pathway and the potassium and
calcium channels are involved in the mechanisms underlying opioid receptor activation. As …

Objectives The aim of this study was to determine whether Ca2+-activated Cl-channels
(CaCCs) are involved in central antinociception induced by the activation of µ-, δ-and κ …

The aim of this study was to examine if the peripheral antinociception of α-bisabolol involves
the participation of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) synthesis …

The involvement of the nitric oxide (NO)/cyclic GMP pathway in the molecular mechanisms
of antinociceptive drugs like morphine has been previously shown by our group …

The present study was designed to investigate the role of Ca2+-activated Cl− channels in
the spinal opioid receptor-mediated antinociception using the mouse tail-flick assay. The …

The modulatory effect of the dihydropyridine Ca2+ channel antagonist nimodipine on the
analgesic action of the κ-opioid receptor agonist U-69,593 was analyzed using the tail-flick …

In order to investigate to the contribution of K+ channels on the peripheral antinociception
induced by diclofenac, we evaluated the effect of several K+ channel blockers, using the rat …

Nitricoxide (NO) has been reported to enhance the analgesic effect of the peripherally
administered [micro sign]-opioid receptor agonists, but the role of NO on the analgesic effect …

BACKGROUND: The involvement of the l-arginine/nitric oxide (NO)/cyclic guanosine
monophosphate (cGMP) pathway in antinociception has been implicated as a molecular …

We examined the effects of amlodipine, a selective L-type voltage dependent Ca2+ channel
(VDCC) blocker, and mibefradil, a selective T-type VDCC blocker on the antinociceptive …