In this study, we investigated the effects of minocycline, a putative suppressor of microglial
activation, on systemic lipopolysaccharide (LPS)-induced spinal cord inflammation …

Perinatal inflammation-induced reduction in pain threshold may alter pain sensitivity to
hyperalgesia or allodynia which may persist into adulthood. In this study, we investigated the …

Systemic injection of lipopolysaccharide (LPS) induces a robust immune response as well
as thermal and mechanical hyperalgesia. Spinal and peripheral glial cells have been …

Neonatal infection is associated with increased lifetime risk for neuropsychiatric disorders
including anxiety and depression, with evidence showing that dysregulation of the …

Background Activation of microglia participates in a wide range of pathophysiological
processes in the central nervous system. Some studies reported that oxycodone (6-deoxy-7 …

Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating
enhanced pain states by releasing proinflammatory cytokines and other substances thought …

Our previous studies have shown that intracerebral administration of endotoxin,
lipopolysaccharide (LPS), induces selective white matter injury and hypomyelination in the …

Many studies have shown that minocycline, an antibacterial tetracycline, suppresses
experimental pain. While minocycline's positive effects on pain resolution suggest that …

Preferential brain white matter injury and hypomyelination induced by intracerebral
administration of the endotoxin lipopolysaccharide (LPS) in the neonatal rat brain has been …

Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …