Pediatric pharmacodynamics of midazolam oral syrup

J Marshall, A Rodarte, J Blumer… - The Journal of …, 2000 - Wiley Online Library
In this study, the authors evaluate the pharmacodynamics, safety, and acceptability of a new
cherry‐flavored oral syrup formulation of midazolam. This randomized, double‐blind …

A comparison of three doses of a commercially prepared oral midazolam syrup in children

CJ Coté, IT Cohen, S Suresh, M Rabb… - Anesthesia & …, 2002 - journals.lww.com
Midazolam is widely used as a preanesthetic medication for children. Prior studies have
used extemporaneous formulations to disguise the bitter taste of IV midazolam and to …

Midazolam premedication in children: a comparison of two oral dosage formulations on sedation score and plasma midazolam levels

KK Brosius, CF Bannister - Anesthesia & Analgesia, 2003 - journals.lww.com
We compared two available oral formulations of midazolam with respect to sedation score
and plasma midazolam levels in pediatric surgical patients 2–10 yr old. The commercially …

A novel, palatable paediatric oral formulation of midazolam: pharmacokinetics, tolerability, efficacy and safety

S Salman, EKY Tang, LC Cheung, MN Nguyen… - …, 2018 - Wiley Online Library
Midazolam is one of many bitter drugs where provision of a suitable oral paediatric
formulation, particularly in the pre‐anaesthetic setting, remains a challenge. To overcome …

The single‐dose pharmacokinetics of midazolam and its primary metabolite in pediatric patients after oral and intravenous administration

MD Reed, A Rodarte, JL Blumer… - The journal of …, 2001 - Wiley Online Library
The first‐dose pharmacokinetics of midazolam and its primary α‐hydroxy metabolite were
studied after single‐dose administration. Eligible study patients were enrolled into one of …

Clinical pharmacology of midazolam in neonates and children: effect of disease—a review

GM Pacifici - International journal of pediatrics, 2014 - Wiley Online Library
Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In
healthy neonates the half‐life (t1/2) and the clearance (Cl) are 3.3‐fold longer and 3.7‐fold …

Premedication of children with oral midazolam

CO McMillan, IA Spahr-Schopfer, N Sikich… - Canadian Journal of …, 1992 - Springer
In a randomized, double-blind, placebo-controlled study, the safety, efficacy and feasibility of
oral midazolam premedication in children were evaluated in an ambulatory surgery unit …

[HTML][HTML] Premedication with midazolam nasal spray: an alternative to oral midazolam in children

RK Verma, A Paswan, A De, S Gupta - Anesthesiology and pain …, 2012 - ncbi.nlm.nih.gov
Background: Midazolam is a water soluble benzodiazepine which is frequently administered
by intravenous and oral routes in our institution. Its nasal spray has become recently …

Oral midazolam in children: effect of time and adjunctive therapy

BC Weldon, MF Watcha, PF White - Anesthesia & Analgesia, 1992 - journals.lww.com
The purpose of this study was to determine the influence of timing and concomitant
administration of atropine and/or meperidine on the perioperative effects of oral midazolam …

Premedication with oral midazolam in children—an assessment of psychomotor function, anxiolysis, sedation and pharmacokinetics

RDM Jones, AR Visram, JP Kornberg… - … and intensive care, 1994 - journals.sagepub.com
We studied 30 children, aged 4 to 12 years, undergoing elective circumcision, premedicated
with midazolam 0.5 mg. kg− 1 and atropine 0.02 mg. kg− 1 by mouth. A modified postbox …