Chronic hepatitis C and persistent occult hepatitis C virus infection are characterized by distinct immune cell cytokine expression profiles

TNQ Pham, SE Mercer, TI Michalak - Journal of viral hepatitis, 2009 - Wiley Online Library
Hepatitis C virus (HCV) replicates in immune cells in both chronic hepatitis C (CHC) and
occult HCV infection, but the extent of virus replication in this compartment in these opposing …

Hepatitis C virus replicates in the same immune cell subsets in chronic hepatitis C and occult infection

TNQ Pham, D King, SA MacParland, JS McGrath… - Gastroenterology, 2008 - Elsevier
Background & Aims: Infection of the lymphatic system by hepatitis C virus (HCV) appears to
be an intrinsic characteristic of chronic hepatitis C (CHC) and low-level (occult) HCV …

Antagonistic expression of hepatitis C virus and alpha interferon in lymphoid cells during persistent occult infection

TNQ Pham, PM Mulrooney‐Cousins… - Journal of Viral …, 2007 - Wiley Online Library
Detection of residual HCV in individuals with SVR after treatment of CHC can be significantly
heightened by analyzing ex vivo mitogen‐activated T and B lymphocytes and applying …

Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C

M Lechmann, RP Woitas, B Langhans, R Kaiser… - Journal of …, 1999 - Elsevier
Background/Aim: Since the outcome of hepatitis C infection appears to be correlated with
the immune response to the HCV core protein, the aim of this study was to investigate the T …

Cytokine Profiles and Hepatic Injury in Occult Hepatitis C Versus Chronic Hepatitis C Virus Infection

N Mousa, W Eldars, H Eldegla… - International journal …, 2014 - journals.sagepub.com
Occult hepatitis C virus (HCV) infection is a new entity that should be considered when
diagnosing patients with abnormal liver functions of unknown origin. This work was carried …

Cytokine mRNA expression in hepatitis C virus infection: TH1 predominance in patients with chronic hepatitis C and TH1–TH2 cytokine profile in subjects with self …

E Gigi, M Raptopoulou‐Gigi, A Kalogeridis… - Journal of viral …, 2008 - Wiley Online Library
Many determinants of the immune response have been implied in the pathogenesis of
chronic hepatitis C. TH1 and TH2 cytokines play a prominent role in viral infections and a …

Different cytokine profiles of peripheral blood mononuclear cells from patients with persistent and self-limited hepatitis C virus infection

M Sarih, N Bouchrit, A Benslimane - Immunology letters, 2000 - Elsevier
An imbalance between T helper cell Th1 and Th2 like cytokines has been described in
several chronic infectious diseases. In an attempt to characterise the mechanism …

[PDF][PDF] Preferential loss of IL‐2–secreting CD4+ T helper cells in chronic HCV infection

N Semmo, CL Day, SM Ward, M Lucas, G Harcourt… - …, 2005 - Wiley Online Library
Hepatitis C virus (HCV) becomes persistent in the majority of infected individuals. In doing
so, the virus evades host adaptive immune responses, although the mechanisms …

Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection

PH McGuinness, D Painter, S Davies, GW McCaughan - Gut, 2000 - gut.bmj.com
BACKGROUND Upregulation of Th1 associated intrahepatic cytokines in chronic hepatitis C
virus (HCV) infection should lead to a significant non-specific cellular immune response, a …

[HTML][HTML] Occult persistence and lymphotropism of hepatitis C virus infection

TNQ Pham, TI Michalak - World Journal of Gastroenterology: WJG, 2008 - ncbi.nlm.nih.gov
Recent discovery of occult hepatitis C virus (HCV) infection persisting after spontaneous or
antiviral therapy-induced resolution of hepatitis C was made possible by the introduction of …