Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers

C Yiyun, X Tongwen - European journal of medicinal chemistry, 2005 - Elsevier
The aqueous solubility of non-steroidal anti-inflammatory drugs (NSAIDs) Ketoprofen,
Ibuprofen, Diflunisal and Naproxen were measured in the presence of the ethylenediamine …

Polyamidoamine Starburst® dendrimers as solubility enhancers

OM Milhem, C Myles, NB McKeown, D Attwood… - International journal of …, 2000 - Elsevier
The solubility of the hydrophobic drug ibuprofen has been compared in an aqueous solution
of polyamidoamine (PAMAM) G4 dendrimer and sodium dodecyl sulphate (SDS). The …

Polyamidoamine dendrimers used as solubility enhancers of ketoprofen

C Yiyun, X Tongwen, F Rongqiang - European Journal of Medicinal …, 2005 - Elsevier
Ketoprofen is a non-steroidal anti-inflammatory drug which is not freely soluble in water and
creates gastrointestinal problems. In the present study we investigated the potential of …

Dendrimers as potential drug carriers. Part II. Prolonged delivery of ketoprofen by in vitro and in vivo studies

M Na, C Yiyun, X Tongwen, D Yang, W Xiaomin… - European Journal of …, 2006 - Elsevier
Ketoprofen, a non-steroidal anti-inflammatory drug with well-known anti-inflammatory,
antipyretic and analgesic properties, has low solubility in water and causes local or systemic …

Solubility of nicotinic acid in polyamidoamine dendrimer solutions

C Yiyun, X Tongwen - European journal of medicinal chemistry, 2005 - Elsevier
In the present study we investigated the effect of ethylenediamine (EDA) core
polyamidoamine (PAMAM) dendrimers on the aqueous solubility of nicotinic acid. The …

[HTML][HTML] Evaluation of poly (amidoamine) dendrimers as potential carriers of iminodiacetic derivatives using solubility studies and 2D-NOESY NMR spectroscopy

M Markowicz, P Szymański, M Ciszewski, A Kłys… - Journal of biological …, 2012 - Springer
The interactions between dendrimers and different types of drugs are nowadays one of the
most actively investigated areas of the pharmaceutical sciences. The interactions between …

Solubility enhancement of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) using polypolypropylene oxide core PAMAM dendrimers

FE Koç, M Şenel - International journal of pharmaceutics, 2013 - Elsevier
The aim of the present study was to evaluate the aqueous solubility enhancement properties
of polypropylene oxide cored PAMAM (PPO@ PAMAM) dendrimers. The solubility of …

[HTML][HTML] Prolonged drug delivery system of an antifungal drug by association with polyamidoamine dendrimers

J Jose, RN Charyulu - International journal of pharmaceutical …, 2016 - ncbi.nlm.nih.gov
Materials and methods: In this research work, we explored the potential of PAMAM
dendrimers to improve the solubility of AmB. Results and discussion: The experimental …

Dendrimers as drug delivery vehicles: non‐covalent interactions of bioactive compounds with dendrimers

HL Crampton, EE Simanek - Polymer international, 2007 - Wiley Online Library
This mini review highlights issues associated with the use of dendrimers as drug delivery
vehicles. The review introduces dendrimers and summarizes findings on their use in vivo …

Application of dendrimer–drug complexation in the enhancement of drug solubility and bioavailability

NK Jain, U Gupta - Expert opinion on drug metabolism & toxicology, 2008 - Taylor & Francis
Dendrimers are 3D, hyperbranched, tree-like polymers having immense potential in drug
delivery, targeting, diagnosis and as carriers for DNA/gene delivery. Dendrimers have …