Only a subgroup of human drug users progress from initial drug taking to drug addiction. The
learned associations between the effects of the drug and the environment in which it is …

Rationale and objectives Drug-seeking behavior occurs more readily in some individuals
than others. This phenomenon is considered in studies of drug self-administration in which …

Background: Substance use disorder emerges in a small proportion of drug users and has
the characteristics of a chronic relapsing pathology. Aims: Our study aimed to demonstrate …

Cocaine has repeatedly been shown to produce conditioned place preference (CPP) in the
rat. The present study employed the heterogenous N/Nih rat stock to produce a selectively …

Reinstatement of drug-seeking behavior in animals is relevant to drug relapse in humans. In
the present study, we employed the conditioned place preference (CPP) paradigm to …

The rewarding effect of cocaine as reflected by the development of conditioned place
preference was examined in C57BL/6J and 129/J mice. Cocaine was administered in a …

It has been shown that pretreatment with dopamine (DA) receptor blockers disrupts the effect
of intravenously (IV) and intracerebrally (ICV), but not intraperitoneally (IP) administered …

To explore sex differences in reinstatement of conditioned place preference, we subjected
intact male and female Long Evans rats to an extended conditioned place preference (CPP) …

Rationale Drug addiction is a multifactorial disorder resulting from an interaction between
genetic and environmental factors, and negative and positive environmental conditions may …

Rationale The place conditioning procedure is increasingly used to study relapse in drug
seeking in mice. However, the retention course of drug-induced place preference has not …