Background. Recent detections of circulating serotype 2 vaccine-derived poliovirus in
northern Nigeria (Borno and Sokoto states) and Pakistan (Balochistan Province) and …

Background The Global Polio Eradication Initiative has achieved its progress through
extensive use of trivalent oral poliovirus vaccine (tOPV, which consists of live, attenuated …

More than 6 decades after licensure of inactivated poliovirus vaccine (IPV) as the first polio
vaccine, optimal use of IPV for polio prevention continues to be an area of interest. With the …

Following the rapid progress towards interrupting indigenous wild poliovirus transmission in
the Americas in the early 1980s, the Global Polio Eradication Initiative (GPEI) was launched …

For more than two decades mankind has been dreaming of a “polio-free world.” However
the dream is yet to be realized owing to various problems related to transmission of wild …

Poliovirus is highly transmissible, with only 1 of every 100 to 1,000 infections among
susceptible individuals resulting in clinically recognizable disease. The origin of global …

Background Despite multiple revisions of targets and timelines in polio eradication plans
since 1988, including changes in supplemental immunization activities (SIAs) that increase …

Background Since the Global Polio Eradication Initiative began, the number of reported
WPV cases has declined from an estimated 350,000 WPV cases in 125 countries during …

Surveillance is a cornerstone of polio eradication efforts. Acute flaccid paralysis (AFP)
surveillance is the primary means of poliovirus detection, supplemented in selected …

Wild poliovirus type 1 (WPV1) transmission remains endemic in Afghanistan and Pakistan.
Outbreaks of paralysis due to circulating vaccine-derived polioviruses (cVDPVs) occur in …