As the vaccine of choice for the Global Polio Eradication Initiative (GPEI), oral poliovirus
vaccine (OPV) is inexpensive, easy to administer, and can provide good protection against …

The Global Polio Laboratory Network (GPLN) isolates and characterizes polioviruses from
fecal specimens of persons with acute flaccid paralysis. The network is coordinated by the …

Background: The Global Polio Eradication Initiative (GPEI) promised to eradicate polio by
2000, yet the disease remains endemic in 2 countries. The current threat of resurgence in …

Since the 1988 World Health Assembly resolution to eradicate poliomyelitis, considerable
progress has been made towards interrupting the transmission of wild poliovirus globally. A …

Abstract The Global Polio Laboratory Network (GPLN) began building in the late 1980s on a
3-tiered structure of 146 laboratories with different and complementary technical and support …

Although global polio eradication is within reach, sustained eradication of all polioviruses
requires cessation of oral poliovirus vaccine use to mitigate against vaccine-derived …

Abstract Poliomyelitis (“polio”) is a disease caused by poliovirus, a small, nonenveloped
icosahedral virus transmitted through the fecal–oral route. Three poliovirus subtypes exist …

With the intensifying global efforts to eradicate wild polioviruses, policymakers face complex
decisions related to achieving eradication and managing posteradication risks. These …

With continued wild poliovirus transmission in Afghanistan and Pakistan and circulating
vaccine-derived poliovirus in certain countries, there exists an ongoing risk of importation of …

Abstract The Global Polio Eradication Initiative (GPEI) has been in operation since 1988,
now spends $1 billion annually, and operates through thousands of staff and millions of …