Performance evaluation of PAMAM dendrimer based simvastatin formulations

H Kulhari, D Pooja, SK Prajapati… - International journal of …, 2011 - Elsevier
The purpose of this investigation was to evaluate the performance of poly
(amidoamine)(PAMAM) dendrimers, with three different surface groups, to be used as drug …

Pharmacokinetic and pharmacodynamic studies of poly (amidoamine) dendrimer based simvastatin oral formulations for the treatment of hypercholesterolemia

H Kulhari, DP Kulhari, SK Prajapati… - Molecular …, 2013 - ACS Publications
The aim of this investigation was to evaluate the in vivo potential of poly (amidoamine)
dendrimers (PAMAM) based simvastatin (SMV) formulations as nanoscale drug delivery …

Poly (amidoamine) dendrimer-mediated hybrid formulation for combination therapy of ramipril and hydrochlorothiazide

MK Singh, D Pooja, H Kulhari, SK Jain, R Sistla… - European Journal of …, 2017 - Elsevier
We present a dendrimer-based hybrid formulation strategy to explore the potential of poly
(amidoamine) PAMAM dendrimers to be used as drug carriers for combination therapy of an …

Dendrimers as versatile platform in drug delivery applications

S Svenson - European Journal of Pharmaceutics and …, 2009 - Elsevier
About forty percent of newly developed drugs are rejected by the pharmaceutical industry
and will never benefit a patient because of poor bioavailability due to low water solubility …

PAMAM dendrimers in drug delivery: Loading efficacy and polymer morphology

P Chanphai, L Bekale… - Canadian Journal of …, 2017 - cdnsciencepub.com
The binding efficacy of anticancer drugs doxorubicin and tamoxifen with polyamidoamine
(PAMAM-G4) dendrimers was studied in aqueous solution at physiological pH. The results …

[PDF][PDF] Dendrimers as potential platform in nanotechnology-based drug delivery systems

NP Silva, FP Menacho, M Chorilli - IOSR journal of pharmacy, 2012 - researchgate.net
The dendrimers of poly (amidoamine)(PAMAM) are nanoparticles which have proven
succeed in transporting drugs due to high solubility, low toxicity and ability to control drugs …

[PDF][PDF] Dendrimers and their applications as novel drug delivery carriers

S Tripathy, MK Das - Journal of Applied Pharmaceutical Science, 2013 - japsonline.com
Dendrimers are novel synthetic polymeric systems having improved physical and chemical
properties due to their unique three dimensional architecture. Dendrimers have a well …

Dendrimers as an effective nanocarrier in cardiovascular disease

A Gothwal, P Kesharwani, U Gupta… - Current …, 2015 - ingentaconnect.com
In the last two decades, dendrimers have proven their capabilities in drug delivery, physical
stabilization of the drug, solubility enhancement of the poorly soluble drugs and gene …

Application of dendrimer–drug complexation in the enhancement of drug solubility and bioavailability

NK Jain, U Gupta - Expert opinion on drug metabolism & toxicology, 2008 - Taylor & Francis
Dendrimers are 3D, hyperbranched, tree-like polymers having immense potential in drug
delivery, targeting, diagnosis and as carriers for DNA/gene delivery. Dendrimers have …

Dendrimers as drug delivery vehicles: non‐covalent interactions of bioactive compounds with dendrimers

HL Crampton, EE Simanek - Polymer international, 2007 - Wiley Online Library
This mini review highlights issues associated with the use of dendrimers as drug delivery
vehicles. The review introduces dendrimers and summarizes findings on their use in vivo …