Recent advances in hormonal male contraception

MC Meriggiola, A Costantino, S Cerpolini - Contraception, 2002 - Elsevier
Hormones inhibit fertility in men by suppressing sperm production. Testosterone-enanthate
induced azoospermia has proven to provide optimal contraceptive protection. Preliminary …

Effects of chronic testosterone administration in normal men: safety and efficacy of high dosage testosterone and parallel dose-dependent suppression of luteinizing …

AM MATSUMOTO - The Journal of Clinical Endocrinology & …, 1990 - academic.oup.com
In normal men, chronic testosterone (T) administration results in negative feedback
suppression of gonadotropin and sperm production. However, azoospermia is achieved in …

Suppression of spermatogenesis with desogestrel and testosterone pellets is not enhanced by addition of finasteride

D Kinniburgh, RA Anderson, DT Baird - Journal of andrology, 2001 - Wiley Online Library
Conversion of testosterone to dihydrotestosterone (DHT) by the action of 5α‐reductase can
amplify androgen action. This may be of particular importance in the presence of low …

A multicenter phase IIb study of a novel combination of intramuscular androgen (testosterone decanoate) and oral progestogen (etonogestrel) for male hormonal …

CJ Hay, BM Brady, M Zitzmann… - The Journal of …, 2005 - academic.oup.com
The effect of a novel combination of oral etonogestrel (ENG) and im testosterone decanoate
(TD) on suppression of gonadotropins and spermatogenesis as a potential lead for male …

Male hormonal contraception

E Nieschlag - Fertility Control, 2010 - Springer
The principle of hormonal male contraception based on suppression of gonadotropins and
spermatogenesis has been established over the last three decades. All hormonal male …

Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: an integrated analysis

PY Liu, RS Swerdloff, BD Anawalt… - The Journal of …, 2008 - academic.oup.com
Context: Male hormonal contraceptive methods require effective suppression of sperm
output. Objective: The objective of the study was to define the covariables that influence the …

Higher testosterone dose impairs sperm suppression induced by a combined androgen‐progestin regimen

MC Meriggiola, A Costantino, WJ Bremner… - Journal of …, 2002 - Wiley Online Library
In this study we compared the effects of high‐dose and low‐dose testosterone enanthate
(TE) administered with the same dose of cyproterone acetate (CPA). Eighteen men aged 21 …

Suppression of spermatogenesis in man induced by Nal-Glu gonadotropin releasing hormone antagonist and testosterone enanthate (TE) is maintained by TE alone

RS Swerdloff, CJ Bagatell, C Wang… - The Journal of …, 1998 - academic.oup.com
GnRH antagonists plus testosterone (T) suppress LH and FSH levels and inhibit
spermatogenesis to azoospermia or severe oligozoospermia. High-dose T treatment alone …

Progress and prospects in male hormonal contraception

JK Amory - Current Opinion in Endocrinology, Diabetes and …, 2008 - journals.lww.com
Testosterone-based hormone combinations are able to reversibly suppress human
spermatogenesis; however, a uniformly effective regimen has remained elusive …

Sperm suppression with monthly injections of medroxyprogesterone acetate combined with testosterone enanthate at a high dose (500 mg)

A Faúndes, V Brache, P León, F Schmidt… - … journal of andrology, 1981 - Wiley Online Library
The combination of an initial injection of 1000 mg of depot medroxyprogesterone acetate
and 500 mg of testosterone enanthate, followed by monthly administration of 150 mg and …