Enhancement of radiation cytotoxicity by UCN-01 in non-small cell lung carcinoma cells
PC Mack, AA Jones, MH Gustafsson… - Radiation …, 2004 - meridian.allenpress.com
Abstract Mack, PC, Jones, AA, Gustafsson, MH, Gandara, DR, Gumerlock, PH and Goldberg,
Z. Enhancement of Radiation Cytotoxicity by UCN-01 in Non-small Cell Lung Carcinoma …
Z. Enhancement of Radiation Cytotoxicity by UCN-01 in Non-small Cell Lung Carcinoma …
Cell cycle-dependent potentiation of cisplatin by UCN-01 in non-small-cell lung carcinoma
PC Mack, DR Gandara, AH Lau, PN Lara… - Cancer chemotherapy …, 2003 - Springer
Purpose We evaluated the combination of UCN-01 plus cisplatin and sought to determine
how the cell cycle effects of each agent affected the combined response. Cisplatin-induced …
how the cell cycle effects of each agent affected the combined response. Cisplatin-induced …
UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53
Q Wang, S Fan, A Eastman, PJ Worland… - JNCI: Journal of the …, 1996 - academic.oup.com
Background: Arrest of the cell cycle in G2 phase following DNA damage helps protect cell
viability by allowing time for DNA repair before entry into mitosis (M phase). Abrogation of …
viability by allowing time for DNA repair before entry into mitosis (M phase). Abrogation of …
RB Status as a Determinant of Response to UCN-01 in Non-Small Cell Lung Carcinoma
PC Mack, DR Gandara, C Bowen, MJ Edelman… - Clinical cancer …, 1999 - AACR
Hydroxystaurosporine (UCN-01), a protein kinase inhibitor in clinical development,
demonstrates potent antineoplastic activity. To determine whether specific genetic …
demonstrates potent antineoplastic activity. To determine whether specific genetic …
7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines
HH Xiao, Y Makeyev, J Butler, B Vikram… - Radiation …, 2002 - meridian.allenpress.com
Abstract Xiao, HH, Makeyev, Y., Butler, J., Vikram, B. and Franklin, WA 7-
Hydroxystaurosporine (UCN-01) Preferentially Sensitizes Cells with a Disrupted TP53 to …
Hydroxystaurosporine (UCN-01) Preferentially Sensitizes Cells with a Disrupted TP53 to …
UCN-01 Inhibits p53 Up-Regulation and Abrogates γ-Radiation-induced G2-M Checkpoint Independently of p53 by Targeting Both of the Checkpoint Kinases, Chk2 …
Q Yu, JH La Rose, H Zhang, H Takemura, KW Kohn… - Cancer research, 2002 - AACR
Abstract UCN-01 (7-hydroxystaurosporine) is a cell-cycle checkpoint abrogator that
sensitizes cells to ionizing radiation (IR) and chemotherapeutic agents. It has been shown …
sensitizes cells to ionizing radiation (IR) and chemotherapeutic agents. It has been shown …
Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell …
LC Playle, DJ Hicks, D Qualtrough… - British journal of …, 2002 - nature.com
Ionising radiation is commonly used in the treatment of colorectal cancer. Tumour cells with
mutant p53 undergo cell cycle arrest at G2/M after ionising radiation and evidence suggests …
mutant p53 undergo cell cycle arrest at G2/M after ionising radiation and evidence suggests …
Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G2 arrest
CB Jones, MK Clements, S Wasi, SS Daoud - Cancer chemotherapy and …, 2000 - Springer
Purpose: To determine the ability of UCN-01 to abrogate the cell cycle arrest induced by
camptothecin (CPT) in tumor cells that lack p53 function, and therefore enhance the …
camptothecin (CPT) in tumor cells that lack p53 function, and therefore enhance the …
UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines
A Monks, ED Harris, A Vaigro-Wolff, CD Hose… - Investigational New …, 2000 - Springer
UCN-01 is undergoing Phase I evaluation and is a candidate forcombination strategies in
the clinic. UCN-01 has been shown to havea variety of effects on cellular targets and the cell …
the clinic. UCN-01 has been shown to havea variety of effects on cellular targets and the cell …
UCN-01-Induced Cell Cycle Arrest Requires the Transcriptional Induction of p21waf1/cip1 by Activation of Mitogen-Activated Protein/Extracellular Signal-Regulated …
MM Facchinetti, A De Siervi, D Toskos… - Cancer research, 2004 - AACR
The small molecule UCN-01 is a cyclin-dependent kinase (CDK) modulator shown to have
antiproliferative effects against several in vitro and in vivo cancer models currently being …
antiproliferative effects against several in vitro and in vivo cancer models currently being …